164584-67-2

Basic information

• Product Name: 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione
• Synonyms: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2-hydroxyethyl)-6-(4-morpholinyl)-; 2-(2-Hydroxyethyl)-6-(morpholin-4-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione; 2-(2-Hydroxy-ethyl)-6-morpholin-4-yl-benzo[de]isoquinoline-1,3-dione
• CAS NO: 164584-67-2
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.3465
• Mol File: 164584-67-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 598.1°C at 760 mmHg
• Flash Point: 315.5°C
• Density: 1.388g/cm³
• Vapor Pressure: 3.73E-15mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione(164584-67-2)
• EPA Substance Registry System: 2-(2-hydroxyethyl)-6-morpholin-4-yl-1H-benzo[de]isoquinoline-1,3(2H)-dione(164584-67-2)

Safety Data

• Hazardous Substances Data: 164584-67-2(Hazardous Substances Data)

Usage

Chemical class

The compound belongs to the class of isoquinoline-1,3-dione derivatives.

Structural features

The compound contains a morpholine ring and a hydroxyethyl group.

Potential pharmaceutical applications

The compound has potential pharmaceutical applications due to its potential biological activities.

Biological activities

The compound has been studied for its potential anticancer and antiproliferative properties.

Therapeutic potential

The compound is being investigated as a therapeutic agent for various diseases, including cancer and neurodegenerative disorders.

Ongoing research

Further research is being conducted to explore the full range of pharmacological effects and applications of this compound.

Upstream product

• 110-91-8 morpholine 
• 52559-37-2 N-hydroxyethyl-4-bromine-1,8-naphthalimide 
• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 
• 31837-36-2 4-(morpholin-4-yl)-1,8-naphthalic anhydride 
• 141-43-5 ethanolamine 

Downstream Products

• 1243675-55-9 C₂₅H₂₅N₃O₃ 

Relevant articles and documents

Synthesis of 4-amino substituted 1,8-naphthalimide derivatives using palladium-mediated amination

Successful amination of 4-bromo-1,8-naphthalimides with 'lengthy' imide N-functionality has been achieved using a general palladium mediated approach (conventional thermal protocols were sub-optimal). Only readily available Pd/ligand combinations were considered and the resulting Buchwald-Hartwig procedure using Pd2(dba)3, Xantphos and Cs 2CO3 is high yielding, relatively mild (40-80 °C, 24 h, yields 50-90%), requires only a modest excess of amine (3.0 equiv) and works equally well with other imide N-substituents. As such, the protocol complements existing methods but is superior for more complex substrates. Herein we compare this Pd mediated approach to the methods most commonly used and further demonstrate its utility by synthesising a number of new, highly fluorescent, 4-aminonaphthalimides.