164592-62-5

Upstream product

• 127258-23-5 (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane 
• 164592-61-4 tert-Butyl-((E)-(1R,4R)-1-dimethoxymethyl-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy)-dimethyl-silane 
• 157837-39-3 Methanesulfonic acid (1S,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2-methyl-propyl ester 
• 157837-49-5 2,2-Dimethyl-propionic acid (E)-(2R,5R)-5-[1,3]dithian-2-yl-2-hydroxy-3-methyl-hex-3-enyl ester 
• 157837-51-9 (E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-en-1-ol 
• 157837-52-0 (E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-[1,3]dithian-2-yl-3-methyl-hex-3-enal 
• 157837-40-6 (2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol 
• 157837-35-9 (R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-[1,3]dithian-2-yl-butan-1-one 
• 157837-43-9 (R)-4-((E)-(R)-3-[1,3]Dithian-2-yl-1-methyl-but-1-enyl)-2,2-dimethyl-[1,3]dioxolane 
• 157837-48-4 (E)-(2R,5R)-5-[1,3]Dithian-2-yl-3-methyl-hex-3-ene-1,2-diol 
• 143619-00-5 Triisopropyl-[(1R,2R,4S)-2-methoxy-4-((R)-(R)-2-oxiranyl-propyl)-cyclohexyloxy]-silane 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 186449-16-1 2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane 
• 157837-32-6 (2S,3R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol 

Downstream Products

• 186449-08-1 C₅₉H₁₀₈O₈S₄Si₂ 
• 164592-79-4 C₅₇H₁₀₂O₇S₄Si₂ 
• 164592-63-6 C₅₈H₁₀₆O₈S₄Si₂ 

Relevant academic research and scientific papers

A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Construction of the C(21-42) perimeters

A total synthesis of the potent, naturally occurring immunomodulators (-)-rapamycin (1) and (-)-27-demethoxyrapamycin (2) has been achieved via a unified, highly convergent synthetic strategy. Both targets were elaborated from common building blocks A-E,