1646-53-3

Basic information

• Product Name: 1-BROMO-2,3,5,6-TETRAMETHYLBENZENE
• Synonyms: BROMODURENE;3-BROMODURENE;3-BROMO-1,2,4,5-TETRAMETHYLBENZENE;1-BROMO-2,3,5,6-TETRAMETHYLBENZENE;TIMTEC-BB SBB008221;2,3,5,6-Tetramethylbromobenzene;Duryl bromide;3-Bromodurene~3-Bromo-1,2,4,5-tetramethylbenzene~2,3,5,6-Tetramethylbromobenzene
• CAS NO: 1646-53-3
• Molecular Formula: C₁₀H₁₃Br
• Molecular Weight: 213.11
• EINECS: 216-707-4
• Mol File: 1646-53-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 60-62 °C(lit.)
• Boiling Point: 111-113 °C6 mm Hg(lit.)
• Flash Point: 115-120°C/5mm
• Appearance: /
• Density: 1.2441 (estimate)
• Vapor Pressure: 0.0245mmHg at 25°C
• Refractive Index: 1.5365 (estimate)
• BRN: 2207158
• CAS DataBase Reference: 1-BROMO-2,3,5,6-TETRAMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2,3,5,6-TETRAMETHYLBENZENE(1646-53-3)
• EPA Substance Registry System: 1-BROMO-2,3,5,6-TETRAMETHYLBENZENE(1646-53-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 1646-53-3(Hazardous Substances Data)

Usage

General Description

1-Bromo-2,3,5,6-tetramethylbenzene is a chemically synthesized compound that finds application primarily in research and chemical laboratories. It posses the molecular formula C10H13Br, and comes as a clear liquid in its pure form. This chemical is aromatic and belongs to the organobromide class of compounds which are organic compounds containing a bromine atom. It is used as a reagent, an intermediate or as a building block in organic synthesis due to its bromo functionality. The chemical's bromine atom can readily be substituted by other functional groups, thereby aiding in the preparation of various aroma compounds, polymers, dyestuffs, pharmaceuticals, and pesticides. It requires careful handling as it may cause eye and skin irritation and is harmful if inhaled or ingested. It is also not classified as a hazardous substance according to environmental regulations.

InChI:InChI=1/C10H13Br/c1-6-5-7(2)9(4)10(11)8(6)3/h5H,1-4H3

Upstream product

• 95-93-2 1,2,4,5-tetramethylbenzene 

Downstream Products

• 41571-62-4 1-bromo-4-iodo-2,3,5,6-tetramethylbenzene 
• 171615-32-0 Bis(2,3,5,6-tetramethylphenylseleno)methane 
• 171615-33-1 Bis(2,3,5,6-tetramethylphenyltelluro)methane 
• 87-85-4 Hexamethylbenzene 
• 18508-46-8 4-bromo-2,3,5,6-tetramethyl-benzyl chloride 
• 3438-34-4 4-Brom-2,3,5,6-tetramethyl-benzotrichlorid 
• 40910-02-9 4-bromo-2,3,5,6-tetramethyl-benzophenone 
• 858836-23-4 1-bromo-2,3,6-trimethyl-4,5-dinitro-benzene 
• 52415-10-8 1-bromo-2,3,5,6-tetramethyl-4-nitrobenzene 
• 2604-45-7 2,3,5,6-tetramethylbenzoic acid 
• 19405-91-5 nitric acid-(3-bromo-2,4,5-trimethyl-6-nitro-benzyl ester) 
• 1646-54-4 1,4-dibromodurene 
• 23851-51-6 1,4-bis-(2,3,5,6-tetramethyl-anilino)-anthraquinone 

Relevant articles and documents

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Metal and H2O2 free aerobic oxidative aromatic halogenation with [RNH3+] [NO3-]/HX and [BMIM(SO3H)][NO3)x(X)y] (X = Br, Cl) as multifunctional ionic liquids

Novel multifunctional ionic liquids (ILs) are generated by addition of HBr or HCl to alkylammonium nitrates ([RNH3+] [NO 3-]) and to 3-methyl-1-(butyl-4-sulfonyl)imidazolium nitrate ([BMIM(SO3H)][NO3]). The resulting [RNH 3+] [NO3-]/HX and mono (3-methyl-1-(butyl-4-sulfonyl)imidazolium) monohalogenide mononitrate ([BMIM(SO3H)][NO3)x(X)y] (X = Br, Cl)) systems act as solvent and promoter for aerobic oxidative halogenation of arenes under mild conditions in high yields that can be repeated over several cycles.

An efficient and regioselective monobromination of electron-rich aromatic compounds using catalytic hypervalent iodine(III) reagent

An efficient and regioselective monobromination of electron-rich aromatic compounds is reported in which iodobenzene is used as the recyclable catalyst in combination with m-chloroperbenzoic acid as the terminal oxidant. The bromination of electron-rich aromatic compounds with lithium bromide was fast in tetrahydrofuran at room temperature, providing regioselective monobrominated products in good yields.