1646-87-3Relevant academic research and scientific papers
Determination of the rate of aldicarb sulphoxidation in rat liver, kidney and lung microsomes
Pelekis,Krishnan
, p. 1113 - 1120 (1997)
1. The rate of sulphoxidation of aldicarb (2-methyl-2-(methylthio) propanal O-[(methylamino) carbonyl oxime], Temik) in rat hepatic, renal and pulmonary microsomes was determined by quantitating the levels of aldicarb sulphoxide and aldicarb sulphone produced during incubations. Under in vitro experimental conditions used in the present study, aldicarb sulphoxide was the only metabolite produced, and further metabolism of aldicarb sulphoxide to aldicarb sulphone was negligible. 2. The average maximal velocity μmol/min/mg protein) for the sulphoxidation of aldicarb, based on measurements of product formation, in liver, kidney and lung microsomes was 5·41, 39·51 and 2·45 respectively. The corresponding values for the Michaelis constant (μM) were 184, 1050 and 188 respectively. 3. These results imply that under in vivo conditions (1) aldicarb sulphoxidation is not likely to be saturable even at lethal doses in the kidney will be limited by the rate of blood flow and not metabolizing enzyme levels.
Catalyse de l'oxydation par l'acid peracetique de sulfures organiques, contenant des fonctions fragiles, en sulfoxydes et sulfones correspondants
Rouchard, Jean,Moons, Chantal,Meyer, Joseph
, p. 441 - 443 (2007/10/02)
Organic sulfur compounds which contained supplementary susceptible functions (oxime, nitrile, acid, alcohol, oximecarbamate) were separately oxidised into the corresponding sulfoxides and sulfones with an anhydrous peracetic acid solution.Molybdenyl acetonylacetonate catalysed the oxidation toward the best conversions of the peracid, and the best selectivities for the sulfoxides and sulfones.
