16462-28-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinecarbonitrile, 4-amino-1,2-dihydro-2-oxo(9CI) is used as a building block in the synthesis of pharmaceuticals for various diseases. Its unique chemical structure allows it to be incorporated into the development of new drugs, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
5-Pyrimidinecarbonitrile, 4-amino-1,2-dihydro-2-oxo(9CI) is also used as an intermediate in the production of pesticides and herbicides. Its versatile properties make it a valuable component in the development of new agrochemicals, which can help improve crop yields and protect plants from pests and diseases.
Used in Chemical and Biological Research:
5-Pyrimidinecarbonitrile, 4-amino-1,2-dihydro-2-oxo(9CI) serves as a research tool in chemical and biological studies. Its unique structure and properties make it an interesting subject for scientific investigations, potentially leading to new insights and discoveries in various fields of research.

InChI:InChI=1/C5H4N4O/c6-1-3-2-8-5(10)9-4(3)7/h2H,(H3,7,8,9,10)

Upstream product

• 16462-29-6 4-amino-2-(ethylthio)pyrimidine-5-carbonitrile 
• 57-13-6 urea 
• 123-06-8 Ethoxymethylenemalononitrile 
• 14048-06-7 (2,2-dicyano-vinyl)-urea 
• 64-17-5 ethanol 
• 94741-70-5 4-Amino-2-bromo-5-pyrimidinecarbonitrile 

Downstream Products

• 120908-32-9 4-amino-5-aminomethyl-1H-pyrimidin-2-one 
• 98021-40-0 4-amino-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid amide 
• 4425-56-3 5-cyanouracil 

Relevant academic research and scientific papers

Synthesis of Janus compounds for the recognition of G-U mismatched nucleobase pairs

The design and synthesis of two Janus-type heterocycles with the capacity to simultaneously recognize guanine and uracyl in G-U mismatched pairs through complementary hydrogen bond pairing is described. Both compounds were conveniently functionalized with

A microwave-assisted high-efficient synthetic 5-cyanogenetic uracil method

The invention relates to a microwave-assisted high-efficiency method for synthesizing 5-cyanouracil, which comprises the following steps: carrying out microwave radiation on urea, malononitrile and triethyl orthoformate at the microwave reaction temperature of 60-80 DEG C under the microwave power of 500W under atmospheric pressure for 8-20 minutes, and filtering the residual triethyl orthoformate out of the reaction system to obtain a dicyan intermediate I; dissolving the obtained solid in a sodium ethylate 1.0-2.0 mol/L solution, carrying out radiation reaction at the microwave reaction temperature of 30-50 DEG C under the microwave power of 300W under atmospheric pressure for 30-50 minutes, adding activated carbon for decolorization, filtering, and acidifying the filtered precipitate with glacial acetic acid to obtain an intermediate II; and adding 2.5-3.0 mol/L dilute hydrochloric acid into the intermediate II, carrying out radiation at the microwave reaction temperature of 80-100 DEG C under the microwave power of 500W under atmospheric pressure for 30-50 minutes, cooling, and filtering to obtain the 5-cyanouracil.