16462-80-9Relevant academic research and scientific papers
Phosphorylation of phenols with diethyl chlorophosphonate on the surface of magnesia
Kaboudin
, p. 402 - 403 (1999)
Phosphorylation of phenols with diethyl chlorophosphonate on the surface of magnesia is an easy, rapid, safe and high-yielding reaction.
A General Strategy for Targeting Drugs to Bone
Jahnke, Wolfgang,Bold, Guido,Marzinzik, Andreas L.,Ofner, Silvio,Pell, Xavier,Cotesta, Simona,Bourgier, Emmanuelle,Lehmann, Sylvie,Henry, Chrystelle,Hemmig, Ren,Stauffer, Frdric,Hartwieg, J. Constanze D.,Green, Jonathan R.,Rondeau, Jean-Michel
supporting information, p. 14575 - 14579 (2016/01/25)
Targeting drugs to their desired site of action can increase their safety and efficacy. Bisphosphonates are prototypical examples of drugs targeted to bone. However, bisphosphonate bone affinity is often considered too strong and cannot be significantly modulated without losing activity on the enzymatic target, farnesyl pyrophosphate synthase (FPPS). Furthermore, bisphosphonate bone affinity comes at the expense of very low and variable oral bioavailability. FPPS inhibitors were developed with a monophosphonate as a bone-affinity tag that confers moderate affinity to bone, which can furthermore be tuned to the desired level, and the relationship between structure and bone affinity was evaluated by using an NMR-based bone-binding assay. The concept of targeting drugs to bone with moderate affinity, while retaining oral bioavailability, has broad application to a variety of other bone-targeted drugs.
Triethylphosphate/phosphorus pentoxide as an efficient reagent for the phosphorylation of phenols
Kaboudin, Babak,Mostafalu, Ramin
experimental part, p. 776 - 780 (2012/06/30)
A simple, efficient, and novel method has been developed for the phosphorylation of phenols. Treatment of phenols with a mixture of triethylphosphate/phosphorus pentoxide gives the corresponding phosphate derivatives in good yields. This method is easy, rapid, and offers good yields for the phosphorylation of phenols. The reaction of triethylphosphate with phosphorus pentoxide was also studied by variable-temperature 31P-NMR spectroscopy. Copyright
