164645-70-9

Upstream product

• 50913-12-7 (2R)-2-(tert-butoxycarbonylamino)-5-[(N-nitrocarbamimidoyl)amino]pentanoic acid 
• 696-60-6 4-aminomethylphenol 
• 164645-69-6 C₁₈H₂₈N₆O₆ 

Downstream Products

• 164646-70-2 (R)-N₅-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N₂-(1-oxo-2-propylpentyl)-ornithinamide 
• 164647-57-8 (R)-N₅-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)-methyl]-N₂-[(2-naphthyl)sulphonyl]-ornithinamide 
• 164645-02-7 (R)-N₅-[amino(nitroimino)methyl]-N₂-[[bis(4-bromophenyl)]acetyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide 
• 164646-54-2 (R)-N₅-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N₂-(phenylacetyl)-ornithinamide 
• 159013-59-9 C₂₇H₃₀N₆O₅ 

Relevant academic research and scientific papers

Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226

Analogues of BIBP 3226, (R)-N(α)-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y1 antagonism (Ca2+-assay, HEl cells) and binding on Y1, Y2 and Y5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y1 activity. Combination with N(G)-phenylpropyl arginine and a N(α)-p-biphenylylacetyl moiety shifted the NPY receptor selectivity towards Y5. (C) 2000 Elsevier Science Ltd. All rights reserved.