951329-18-3

Upstream product

• 164648-75-3 4-(aminomethyl)-2,6-dichloroaniline 
• 951328-89-5 (S)-tert-butyl N-(1-(4-methoxyphenyl)pyrrolidine-5-carbonyl)(methylthio)carbonoimidoylcarbamate 

Downstream Products

• 951329-24-1 C₂₇H₃₂BrCl₂N₅O₅ 

Relevant academic research and scientific papers

N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors

There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.