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164662-48-0

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164662-48-0 Usage

Chemical structure

The compound has a quinoline core with a carboxylic acid group attached, a fluoro substituent, and a piperazine moiety.

Molecular weight

Approximately 427.46 g/mol

Appearance

The compound is likely to be a solid, possibly in the form of a crystalline powder.

Solubility

The compound may be soluble in organic solvents such as methanol, ethanol, or dimethyl sulfoxide (DMSO), but its solubility in water is not specified.

Pharmacological activity

The compound has potential pharmacological activity due to its quinolone structure, which is known for its antibacterial properties.

Biological activity

The presence of a piperazine group suggests potential biological activity, which could be relevant for the development of new drugs or other applications in the pharmaceutical industry.

Stability

The stability of the compound under various conditions (e.g., temperature, pH, light exposure) is not specified and would require further investigation.

Synthesis

The synthesis of the compound would involve the formation of the quinoline core, introduction of the carboxylic acid group, and subsequent functionalization with the fluoro substituent and piperazine moiety.

Purity

The purity of the compound would depend on the synthesis method and purification techniques employed, which could affect its pharmacological and biological properties.

Toxicity

The toxicity of the compound is not specified and would require further investigation to determine its safety for potential pharmaceutical applications.

Drug development

Understanding the chemical and biological properties of this compound could be important for the development of new drugs or other applications in the pharmaceutical industry, particularly in the areas of antibacterial and other therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 164662-48-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,6,6 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 164662-48:
(8*1)+(7*6)+(6*4)+(5*6)+(4*6)+(3*2)+(2*4)+(1*8)=150
150 % 10 = 0
So 164662-48-0 is a valid CAS Registry Number.

164662-48-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,4-dimethylphenyl)-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 3-Quinolinecarboxylic acid,1-(2,4-dimethylphenyl)-7-(3,5-dimethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:164662-48-0 SDS

164662-48-0Downstream Products

164662-48-0Relevant articles and documents

Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria

Renau, Thomas E.,Sanchez, Joseph P.,Shapiro, Martin A.,Dever, Julie A.,Gracheck, Stephen J.,Domagala, John M.

, p. 2974 - 2977 (2007/10/02)

The dramatic increase in drug resistant Mycobacterium tuberculosis has caused a resurgence in research targeted toward these organisms.As part of a systematic study to optimize the quinolone antibacterials against mycobacteria, we have prepared a series of N-1-phenyl-substituted derivatives to explore the effect of increasing lipophilicity on potency at this position.The compounds, synthesized by the modification of a literature procedure, were evaluated for activity against Gram-negative and Gram-positive bacteria, Mycobacterium fortuitum and Mycobacterium smegmatis, and the results correlated with log P, pKa, and other attributes.The activity of the compounds against the rapidly growing, less hazardous organism M. fortuitum was used as a measure of M. tuberculosis activity.The results demonstrate that increasing lipophilic character by itself does not correlate with increased potency against mycobacteria.Rather, intrinsic activity against Gram-negative and/or Gram-positive bacteria is the governing factor for corresponding activity against mycobacteria.

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