164664-96-4Relevant academic research and scientific papers
Fast and efficient microwave synthetic methods for some new 2(1H)-pyridone arabinosides
Abdou, Ibrahim M.,Rateb, Nora M.,Eldeab, Hany A.
, p. 135 - 141 (2012)
Two series of novel 3-cyano-2-(2'' ,3'' ,4'' -tri- O - acetyl- β - d -arabinopyranosyloxy)pyridones 5a - h and 9a,b were synthesized. Microwave irradiation has been used to obtain these products in high yield under milder conditions by the reaction of 2(1 H )-pyridone or its salt with an activated arabinose. The silyl method was used to obtain the same nucleosides 5a - h and 9a,b . Triethylamine was used to remove the acetyl protecting groups from the sugar moiety and to produce the free nucleosides 6a - h and 10a,b in 85 - 91% yield.
An eco-friendly technique: Solvent-free microwave synthesis and docking studies of some new pyridine nucleosides and their pharmacological significance
Alrobaian, Majed,Al Azwari, Sana,Belal, Amany,Eldeab, Hany A.
, (2019)
Two series of novel 5-arylazo-3-cyano-2-(2",3",4",6"-tetra-O-acetyl-β-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2",3",4",6"-tetra-O-acetyl-β-d-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).
