16469-62-8

Basic information

• Product Name: pent-1-yn-3-one
• Synonyms: 1-Pentyne-3-one; Pent-1-yn-3-one
• CAS NO: 16469-62-8
• Molecular Formula: C₅H₆O
• Molecular Weight: 82.1005
• Mol File: 16469-62-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 110.9°C at 760 mmHg
• Flash Point: 30.1°C
• Density: 0.892g/cm³
• Vapor Pressure: 23.3mmHg at 25°C
• Refractive Index: 1.415
• CAS DataBase Reference: pent-1-yn-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: pent-1-yn-3-one(16469-62-8)
• EPA Substance Registry System: pent-1-yn-3-one(16469-62-8)

Safety Data

• Hazardous Substances Data: 16469-62-8(Hazardous Substances Data)

Upstream product

• 4187-86-4 pent-1-yn-3-ol 
• 79-03-8 propionyl chloride 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 18387-58-1 1-(trimethylsilyl)-1-pentyne-3-one 

Downstream Products

• 17421-62-4 β-Triaethylstannylvinylaethylaether 
• 4187-86-4 pent-1-yn-3-ol 
• 126971-25-3 C₃₀H₃₂O₂ 

Relevant articles and documents

3-BocNH-ABNO-catalyzed aerobic oxidation of alcohol at room temperature and atmospheric pressure

A transition-metal-free catalytic system has been developed for selective transformation of alcohol to aldehydes or ketones. The reactions were performed with 3-(tert-butoxycarbonylamino)-9-azabicyclo[3.3.1]nonane N-oxyl (3-BocNH-ABNO) as the catalyst, NaNO2 as the co-catalyst, molecular oxygen as the terminal oxidant, and AcOH as the solvent under room temperature. This catalytic system exhibited broad functional group tolerance. A series of alcohol substrates, including primary and secondary benzylic alcohols, heteroaromatic analogues, primary and secondary aliphatic alcohols, could be converted into their corresponding aldehydes and ketones in good conversions and selectivities.

Efficient aerobic oxidation of secondary alcohols at ambient temperature with an ABNO/NOx catalyst system

New highly practical methods are presented for aerobic oxidation of secondary alcohols with a nitroxyl radical in combination with HNO3, NaNO2, or both as cocatalysts. Diverse nitroxyls are compared, including several novel bicyclic derivatives. Catalyst systems with the readily available nitroxyls, 9-azabicyclo[3.3.1]nonane-N-oxyl (ABNO) and 9-azabicyclo[3.3.1]nonan-3-one-N-oxyl (keto-ABNO), are optimized in acetic acid or acetonitrile as the solvent. The reactions are compatible with substrates bearing diverse functional groups and proceed efficiently under mild conditions at ambient pressure and temperature.

Asymmetric reduction of ethynyl ketones and ethynylketoesters by secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus

Secondary alcohol dehydrogenase (SADH) from Thermoanaerobacter ethanolicus, an NADP-dependent, thermostable oxidoreductase, reduces ethynyl ketones and ethynylketoesters enantioselectively to the corresponding propargyl (propargyl = prop-2-ynyl) alcohols. Ethynyl ketones, in general, are reduced with moderate enantioselectivity (with the exception of 4-methylpent-l-yn-3-one, which gives the (S)-alcohol with >98% ee). Although ethynyl ketones bearing a small (up to n-propyl) alkyl substituent are reduced to (S)-alcohols, larger ethynyl ketones give (R)-alcohols. In contrast, ethynylketoesters are converted to (R)-ethynylhydroxyesters of excellent optical purity. Unexpectedly, isopropyl ethynylketoesters give higher chemical yields and higher enantioselectivities of ethynylhydroxyesters than methyl or ethyl ethynylketoesters. The optically pure ethynylhydroxyesters may serve as useful chiral building blocks for asymmetric synthesis.