1647073-82-2Relevant academic research and scientific papers
Copper-mediated ortho-nitration of (hetero)arenecarboxylates
Katayev, Dmitry,Pfister, Kai F.,Wendling, Timo,Goossen, Lukas J.
, p. 9902 - 9905 (2014/08/18)
Various (hetero)arenecarboxylic acids were converted to the corresponding Daugulis amides and nitrated selectively in the ortho-position in the presence of [CuNO3(PPh3)2] and AgNO2 at 50 °C. A microwave-assisted saponification allows regenerating the carboxylate group within minutes, which may then be removed tracelessly by protodecarboxylation, or substituted by aryl- or alkoxy-groups via decarboxylative cross-coupling.
