1647091-57-3

Upstream product

• 75-52-5 nitromethane 
• 51758-24-8 4-phenyl-4-penten-1-al 
• 93222-37-8 4-phenylpent-4-en-1-ol 
• 2051-95-8 succinylbenzene 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 93863-05-9 4-phenylpent-4-enoic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective synthesis of tetrahydrofuran derivatives by sequential henry reaction and iodocyclization of γ,δ-unsaturated alcohols

A sequential one-pot Cu-catalyzed asymmetric Henry reaction and iodocyclization is disclosed. The transformation provides efficient access to biologically and synthetically useful 2,2,5-trisubstituted tetrahydrofuran derivatives. The combination of Cu(OAc)2·H2O with a novel chiral sulfoxide-Schiff base hybrid ligand under mild reaction conditions tolerates a wide range of 4-substituted γ,δ-unsaturated aldehydes, and the subsequent iodocyclization furnishes the corresponding products in generally high yields with excellent enantioselectivities. The products can be easily converted into amines with excellent diastereo- and enantioselectivities.