164721-12-4

Basic information

• Product Name: 1-(4-fluorophenyl)piperidin-4-amine
• Synonyms: 1-(4-fluorophenyl)piperidin-4-amine(SALTDATA: CH3COOH);1-(4-fluorophenyl)piperidin-4-amine;UKRORGSYN-BB BBV-080348
• CAS NO: 164721-12-4
• Molecular Formula: C₁₁H₁₅FN₂
• Molecular Weight: 194.25
• Mol File: 164721-12-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 310.5°C at 760 mmHg
• Flash Point: 141.6°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0.000599mmHg at 25°C
• Refractive Index: 1.542
• PKA: 10.08±0.20(Predicted)
• CAS DataBase Reference: 1-(4-fluorophenyl)piperidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)piperidin-4-amine(164721-12-4)
• EPA Substance Registry System: 1-(4-fluorophenyl)piperidin-4-amine(164721-12-4)

Safety Data

• Hazardous Substances Data: 164721-12-4(Hazardous Substances Data)

Usage

General Description

1-(4-fluorophenyl)piperidin-4-amine is a chemical compound consisting of a piperidine ring with a 4-fluorophenyl group and an amine group. It is used in the synthesis of various pharmaceutical drugs, particularly in the development of psychoactive substances and medications for central nervous system disorders. 1-(4-fluorophenyl)piperidin-4-amine is of interest in medicinal chemistry research due to its potential therapeutic applications and its ability to interact with biological targets in the brain. Additionally, its structure and properties make it an important building block for the synthesis of new chemical entities for drug discovery and development.

InChI:InChI=1/C11H15FN2/c12-9-1-3-11(4-2-9)14-7-5-10(13)6-8-14/h1-4,10H,5-8,13H2

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 483366-29-6 tert-butyl N-[1-(4-fluorophenyl)piperidin-4-yl]carbamate 

Downstream Products

• 1429217-44-6 N-(1-(4-fluorophenyl)piperidin-4-yl)-3-methoxy-2-oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydropyridine-4-carboxamide 
• 164720-77-8 4-[N-(4-Fluorophenyl)piperidin-4-ylamino]-3-chloro-2-methylpyridine 

Relevant articles and documents

INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE

Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.