16473-21-5Relevant articles and documents
The transmission of resonance effects through a methylene group-spectroscopic studies on some α-substituted-acetonitriles and p-toluonitriles
Butt, G.,Cilmi, J.,Hoobin, P. M.,Topsom, R. D.
, p. 521 - 524 (1980)
Frequencies and integrated intensities are recorded for the νCN mode of a representative selection of α-substituted acetonitriles, α-substituted-p-toluonitriles and β-substituted propionitriles.The frequencies of the acetonitriles are confirmed
METHOD AND REAGENT FOR DEOXYFLUORINATION
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Paragraph 0148-0150; 0152; 0156, (2021/05/29)
A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.
Deoxyfluorination of alcohols with aryl fluorosulfonates
Fei, Zhongbo,Hu, Jinbo,Li, Wei,Liu, Qinghe,Ni, Chuanfa,Wang, Xiu,Zhou, Min
supporting information, p. 8170 - 8173 (2021/08/23)
Aryl fluorosulfonates are developed as a deoxyfluorinating reagent in the transformation of primary and secondary alcohols into the corresponding alkyl fluorides. These reagents feature easy availability, low-cost, high stability and high efficiency. Diverse functionalities including aldehyde, ketone, ester, halogen, nitro, alkene, and alkyne are well tolerated under mild reaction conditions.