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16475-76-6

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16475-76-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 16475-76-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,7 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16475-76:
(7*1)+(6*6)+(5*4)+(4*7)+(3*5)+(2*7)+(1*6)=126
126 % 10 = 6
So 16475-76-6 is a valid CAS Registry Number.

16475-76-6Relevant articles and documents

Novel 3,6,7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A)

Blad, Clara C.,Van Veldhoven, Jacobus P. D.,Klopman, Corné,Wolfram, Dieter R.,Brussee, Johannes,Lane, J. Robert,Ijzerman, Adriaan P.

supporting information; experimental part, p. 3563 - 3567 (2012/06/04)

A number of pyrazolopyrimidines were synthesized and tested for their positive allosteric modulation of the HCA2 receptor (GPR109A). Compound 24, an efficacious and potent agonist and allosteric enhancer of nicotinic acid's action, was the basis for most other compounds. Interestingly, some of the compounds were found to increase the efficacy of the endogenous ligand 3-hydroxybutyrate and enhance its potency almost 10-fold. This suggests that the pyrazolopyrimidines may have therapeutic value when given alone.

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