1648787-33-0Relevant academic research and scientific papers
Rhodium-Catalyzed One-Pot Access to N-Polycyclic Aromatic Hydrocarbons from Aryl Ketones through Triple C-H Bond Activations
Biswal, Pragati,Banjare, Shyam Kumar,Pati, Bedadyuti Vedvyas,Mohanty, Smruti Ranjan,Ravikumar, Ponneri Chandrababu
, p. 1108 - 1117 (2021)
A Rh-catalyzed pot and step economic synthesis of aza-polycyclic aromatic hydrocarbons (N-PAHs) from readily available aryl ketones and alkynes has been disclosed. Additionally, a novel synthetic application of the well-known aminating reagent hydroxylamine-O-sulfonic acid (HOSA) has been explored as an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline. Multiple bond formation in a single operation through a cascade of triple C-H bond activations is the beauty of this protocol. The challenging annulations of two different alkynes in a regioselective fashion have been demonstrated effectively. Mechanistic studies reveal that 3,4-diphenyl-1-methylisoquinoline is an active intermediate for this one-pot transformation.
Synthesis of sterically congested polycyclic aromatic hydrocarbons: Rhodium(III)-catalyzed cascade oxidative annulation of aryl ketoximes with diphenylacetylene by sequential cleavage of multiple C-H bonds
Liu, Bin,Hu, Fang,Shi, Bing-Feng
, p. 2688 - 2696 (2014/09/17)
The rhodium(III)-catalyzed oxidative annulations of aryl ketoximes with diphenylacetylene by the cleavage of three C-H bonds, one C-O bond and the formation of four C-C bonds, one C-N bonds simultaneously have been developed. This protocol is scalable and
