16488-60-1

Usage

Uses

Used in Organic Synthesis:
2,5-Diiodo-3-methylthiophene is used as a building block in organic synthesis for its unique reactivity and structural properties. It serves as a key intermediate in the production of various compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Diiodo-3-methylthiophene is used as a precursor for the development of new pharmaceuticals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Industry:
2,5-Diiodo-3-methylthiophene is also utilized as a starting material in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Materials Science:
In the field of materials science, 2,5-Diiodo-3-methylthiophene is employed in the development of new materials with specific properties, such as electronic or optical characteristics, due to its unique molecular structure.

Upstream product

• 616-44-4 3-Methylthiophene 
• 23806-24-8 3-methyl-2-thiophenecarboxylic acid 

Downstream Products

• 75376-73-7 2,5-dimethoxy-3-methylthiophen 

Relevant academic research and scientific papers

Method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction

The invention discloses a method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction. The method is characterized in that under a protective atmosphere, carrying out one-pot reaction on a

Green halogenation of aromatic heterocycles using ammonium halide and hydrogen peroxide in acetic acid solvent

The green generation of X+ (X = Br, I) using hydrogen peroxide in aqueous acetic acid allows access to aromatic heterocyclic halides in yields and purities comparable to syntheses employing N-bromosuccinimide. In activated and unsubstituted thiophene rings, regioselectivity is quantitative for positions α to the sulfur; pyrroles also give quantitative reactions, at least initially. Deactivated rings, including furans and thiazoles, as well as thiophenes with strongly electron-withdrawing groups showed little to no reactivity under the conditions investigated. The reaction shows remarkable functional group tolerance (to alcohol, nitro, alkyl, halo, and carbonyl groups), as shown through reaction with substituted phenols. In all bromination reactions, reaction yields and regiochemistry were very similar to reactions involving N-bromosuccinimide in tetrahydrofuran solvent.

Halogenation Using Quaternary Ammonium Polyhalides. XXXI. Halogenation of Thiophene Derivatives with Benzyltrimethylammonium Polyhalides

The reactions of thiophene derivatives with benzyltrimethylammonium tetrachloroiodate, benzyltrimethylammonium tribromide, and benzyltrimethylammonium dichloroiodate in acetic acid or in acetic acid-zinc chloride under mild conditions gave chloro-, bromo-, and iodo-substituted thiophene derivatives, respectively, in satifactory yields.

Ring-opening Reactions. Part 16. Ring-opening of 2,5-Dimethoxy-3-thienyl-lithium and Some Related Compounds

Evidence is presented indicating that 2,5-dimethoxythiophen is metallated in the β-position by butyl-lithium to give 2,5-dimethoxy-3-thienyl-lithium, which subsequently undergoes ring-opening.By the use of 2 equiv. of butyl-lithium followed by dimethyl sulphate, it was possible to isolate 1-methylthio-octa-1,3-diyne as the main product.