1649440-15-2Relevant academic research and scientific papers
Synthesis, structure elucidation, antioxidant and antimicrobial activity of novel 2-(5-trifluoromethyl-1H-pyrazol-1-yl)-5-(5-trihalomethyl-1H-pyrazol-1-yl-1-carbonyl)pyridines
Bonacorso, Helio G.,Cavinatto, Susiane,Moraes, Maiara C.,Pittaluga, Everton P.,Peroza, Luis R.,Venturini, Tarcieli,Alves, Sydney H.,Stefanello, Sílvio T.,Soares, Félix A. A.,Martins, Marcos A. P.,Zanatta, Nilo,Frizzo, Clarissa P.
, p. 2346 - 2361 (2015/11/10)
This paper describes an efficient approach for the synthesis of a novel series of sixteen 2-(5-trifluoromethyl-1H-pyrazol-1-yl)-5-(5-trihalomethyl-1H-pyrazol-1-yl-1-carbonyl) pyridines, for the first time with non-identical substituents in both pyrazole r
New pyrazolyl-nicotinic acids, methyl esters, and 1,3,4-oxadiazolyl- pyrazolyl-pyridine tricyclic scaffold derivatives from 6-hydrazinylnicotinic acid hydrazide hydrate
Bonacorso,Paim,Porte,Pittaluga,Cavinatto,Meyer,Martins,Zanatta
, p. 1171 - 1178 (2014/08/05)
This paper describes an efficient approach for the synthesis of a new series of 6-[3-alkyl(aryl/heteroaryl)-5-trifluoromethyl-1H-pyrazol-1-yl] nicotinic acids (where alkyl = CH3; aryl = Ph, 4-OCH3Ph, 4,4′-BiPh; and heteroaryl = 2-Furyl) from the hydrolysis reaction of alkyl(aryl/heteroaryl)substituted 2-(5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H- pyrazol-1-yl)-5-(5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-1-carbonylpyrazol-1- yl)pyridines, under basic conditions and at 70-95% yields. In a subsequent step, the esterification reaction of pyrazolyl-nicotinic acids done in thionyl chloride and methanol led to the isolation of a series of methyl 6-[alkyl(aryl/heteroaryl)-5-trifluoromethyl-1H-pyrazol-1-yl] nicotinates as stable hydrochloride salts at 64-84% yields, which could be easily converted to hydrazides to give new oxadiazolyl-pyrazolyl-pyridine tricyclic scaffolds at good yields from a [4 + 1] cyclocondensation reaction with 1,1,1-triethoxyethane and 1-(triethoxymethyl)benzene as the reagent/solvent.
