1649440-23-2

Upstream product

• 1649440-06-1 methyl 6-(5-trifluoromethyl-3-phenyl-1H-pyrazol-1-yl)nicotinate hydrochloride 
• 1649440-15-2 6-(5-trifluoromethyl-3-phenyl-1H-pyrazol-1-yl)nicotinohydrazide 
• 1663-61-2 triethoxymethylbenzene 
• 1649439-93-9 C₂₆H₁₉F₆N₅O₃ 
• 1649439-98-4 6-(5-trifluoromethyl-3-phenyl-1H-pyrazol-1-yl)nicotinic acid 

Relevant academic research and scientific papers

New pyrazolyl-nicotinic acids, methyl esters, and 1,3,4-oxadiazolyl- pyrazolyl-pyridine tricyclic scaffold derivatives from 6-hydrazinylnicotinic acid hydrazide hydrate

This paper describes an efficient approach for the synthesis of a new series of 6-[3-alkyl(aryl/heteroaryl)-5-trifluoromethyl-1H-pyrazol-1-yl] nicotinic acids (where alkyl = CH3; aryl = Ph, 4-OCH3Ph, 4,4′-BiPh; and heteroaryl = 2-Furyl) from the hydrolysis reaction of alkyl(aryl/heteroaryl)substituted 2-(5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H- pyrazol-1-yl)-5-(5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-1-carbonylpyrazol-1- yl)pyridines, under basic conditions and at 70-95% yields. In a subsequent step, the esterification reaction of pyrazolyl-nicotinic acids done in thionyl chloride and methanol led to the isolation of a series of methyl 6-[alkyl(aryl/heteroaryl)-5-trifluoromethyl-1H-pyrazol-1-yl] nicotinates as stable hydrochloride salts at 64-84% yields, which could be easily converted to hydrazides to give new oxadiazolyl-pyrazolyl-pyridine tricyclic scaffolds at good yields from a [4 + 1] cyclocondensation reaction with 1,1,1-triethoxyethane and 1-(triethoxymethyl)benzene as the reagent/solvent.