1649461-22-2

Upstream product

• 243665-98-7 7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 243665-86-3 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones and their N-alkylation's under phase transfer conditions

5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were synthesized by the cyclocondensation of 1,4-disubstituted 2-amino-3-cyanopyrrole 1 with formic acid. When comparative study of N versus O alkylation of ambident 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 was carried out under liquid-liquid PTC, solid-liquid PTC, and solid-liquid solvent free conditions using various alkylating agents 3, the N-alkylated product 4 were obtained selectively and exclusively.