16497-36-2Relevant academic research and scientific papers
Reaction of N-Arylphthalisoimidium Perchlorates with Amines and Aromatic Hydrocarbons under Friedel-Crafts Conditions, a New and Convenient One-Step Method for the Synthesis of 2,3-Diaryl-3-hydroxyphthalimidines
Ismail, M. Fekry,Enayat, E. I.,El-Bassiouny, F. A.,Younes, H. A.
, p. 707 - 710 (2007/10/02)
N-Arylphthalisoimidium perchlorates (1a, b) react with primary amines via ring-opening to give N,N'-disubstituted phthalamides (3a-d).They react with aromatic hydrocarbons under Friedel-Crafts conditions to give 2,3-diaryl-3-hydroxyphthalimidines (a-i) while the reaction of 1a wtith phenylmagnesium bromide involved just deprotonation to the isoimide (9) followed by rearrangement to N-phenylphthalimide (8).
FEATURES OF THE REACTION OF PHTHALOYL CHLORIDE WITH PRIMARY AMINES
Ganin, E. V.,Makarov, V. F.,Rozynov, B. V.
, p. 1772 - 1777 (2007/10/02)
The reaction of phthaloyl chloride with primary amines, which leads to the formation of the N,N'-substituted diamides of phthalic acid, takes place through the intermediate formation of the N-substituted isophthalimides.The reactivity of these compounds i
