16499-52-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Nitro-5-(trifluoromethyl)benzonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure of these compounds can contribute to their therapeutic properties, making it an essential component in drug development.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Nitro-5-(trifluoromethyl)benzonitrile is utilized as a precursor in the production of agrochemicals. Its unique functional groups can be incorporated into the design of new pesticides or herbicides, enhancing their effectiveness in agricultural applications.
Used in Organic Synthesis:
2-Nitro-5-(trifluoromethyl)benzonitrile is used as a valuable intermediate in the synthesis of complex organic compounds. Its versatile structure allows for various chemical reactions, facilitating the creation of a wide range of organic molecules with diverse applications.
Used as a Reagent in Organic Reactions:
2-Nitro-5-(trifluoromethyl)benzonitrile also serves as an important reagent in organic chemistry, enabling specific transformations and reactions that are crucial for the synthesis of target molecules. Its presence can influence the outcome of these reactions, making it a vital tool in the field of organic chemistry.

InChI:InChI=1/C8H3F3N2O2/c9-8(10,11)6-1-2-7(13(14)15)5(3-6)4-12/h1-3H

Upstream product

• 773837-37-9 sodium cyanide 
• 402-14-2 2-nitro-5-(trifluoromethyl)aniline 
• 1176723-57-1 2-nitro-5-(trifluoromethyl)benzaldehyde 
• 151-50-8 potassium cyanide 

Downstream Products

• 16499-54-0 2-amino-5-(trifluoromethyl)benzamide 
• 16499-68-6 2-Nitro-5-trifluormethyl-benzamid 

Relevant academic research and scientific papers

Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products

A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]quinazolin-8-one.

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.