16499-52-8 Usage
General Description
2-Nitro-5-(trifluoromethyl)benzonitrile is a chemical compound with the molecular formula C8H3F3N2O2. It is a nitrobenzonitrile derivative, which means it contains a nitro group and a nitrile group attached to a benzene ring. The trifluoromethyl group, consisting of three fluorine atoms, is also attached to the benzene ring. 2-Nitro-5-(trifluoromethyl)benzonitrile is a versatile building block in organic synthesis and is used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and functional groups make it a valuable intermediate in the synthesis of various complex organic compounds. It is also used as a reagent in organic reactions, making it an important compound in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 16499-52-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,9 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16499-52:
(7*1)+(6*6)+(5*4)+(4*9)+(3*9)+(2*5)+(1*2)=138
138 % 10 = 8
So 16499-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H3F3N2O2/c9-8(10,11)6-1-2-7(13(14)15)5(3-6)4-12/h1-3H
16499-52-8Relevant articles and documents
Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products
Pal, Shantanu,Sahoo, Subrata
, p. 18067 - 18080 (2021/12/06)
A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]quinazolin-8-one.
