16499-54-0

Basic information

• Product Name: 2-AMino-5-trifluoroMethylbenzaMide
• Synonyms: 2-AMino-5-trifluoroMethylbenzaMide
• CAS NO: 16499-54-0
• Molecular Formula: C₈H₇F₃N₂O
• Molecular Weight: 204.1491896
• Mol File: 16499-54-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 258.3±40.0 oC (760 Torr), Calc.*
• Flash Point: 110.0±27.3 oC, Calc.*
• Appearance: /
• Density: 1.418±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• PKA: 15.08±0.50(Predicted)
• CAS DataBase Reference: 2-AMino-5-trifluoroMethylbenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-trifluoroMethylbenzaMide(16499-54-0)
• EPA Substance Registry System: 2-AMino-5-trifluoroMethylbenzaMide(16499-54-0)

Safety Data

• Hazardous Substances Data: 16499-54-0(Hazardous Substances Data)

Usage

General Description

2-Amino-5-trifluoromethylbenzamide is an organic compound that contains an amino group and a trifluoromethyl group attached to a benzene ring. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-AMino-5-trifluoroMethylbenzaMide has been found to exhibit anti-inflammatory and analgesic properties, and it has been studied for its potential use in treating various diseases and conditions. Its unique chemical structure and properties make it a valuable tool for researchers and chemists in the development of new medicinal compounds.

Upstream product

• 1176723-57-1 2-nitro-5-(trifluoromethyl)benzaldehyde 
• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 781-94-2 6-(trifluoromethyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 887144-94-7 Togni's reagent II 
• 28144-70-9 anthranilic acid amide 
• 402-14-2 2-nitro-5-(trifluoromethyl)aniline 
• 16499-52-8 2-nitro-5-(trifluoromethyl)benzonitrile 
• 16499-68-6 2-Nitro-5-trifluormethyl-benzamid 

Relevant articles and documents

Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products

A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]quinazolin-8-one.

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.