16503-81-4

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 1895-39-2 sodium chlorodifluoroacetate 
• 18803-44-6 sodium p-chlorothiophenolate 
• 676316-30-6 4-chlorophenylthiodifluoroacetic acid chloride 

Downstream Products

• 1563062-31-6 ethyl ({[(4-chlorophenyl)sulfanyl]difluoromethyl}sulfanyl)methanethioate 
• 1563062-69-0 4-[(4-chlorophenyl)sulfanyl]-2-[(ethoxymethanethioyl)sulfanyl]-4,4-difluorobutyl acetate 
• 1563062-70-3 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-cyano-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-79-2 (4-chlorophenyl)(1,1-difluoro-2-(4-isopropylcyclohex-1-enyl)ethyl)sulfane 
• 1563062-82-7 2-(4-(4-chlorophenylthio)-4,4-difluorobutyl)phthalimide 
• 1563062-84-9 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide 
• 1563062-49-6 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-96-3 6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran 
• 1563063-04-6 ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-[N-(4-methoxyphenyl)methanesulfonamido]butan-2-yl}sulfanyl)methanethioate 
• 1563063-05-7 N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide 
• 1563063-08-0 C₁₈H₁₈ClF₂NO₃S₂ 
• 1563062-54-3 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(2,6-dioxopiperidin-1-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-56-5 methyl 12-[(4-chlorophenyl)sulfanyl]-10-[(ethoxymethanethioyl)sulfanyl]-12,12-difluorododecanoate 
• 1563063-02-4 3-(6-chloro-2,2-difluorothiochroman-4-yl)-1-(4-methoxyphenyl)propan-1-one 

Relevant academic research and scientific papers

Silver-Catalyzed C-H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes

The oxidative C-H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reac

Radical coupling of arylthiodifluoroacetic acids and ethynylbenziodoxolone (EBX) reagents to access arylthiodifluoromethylated alkynes

A practical and efficient radical coupling of easily available arylthiodifluoroacetic acids and ethynylbenziodoxolone (EBX) reagents has been reported. Under transition metal-free conditions, aryl-substituted EBXs were converted to the corresponding ArSCF2-substituted alkynes in moderate to good yields, whereas TIPS-EBX underwent silver-catalyzed decarboxylative conditions to deliver the desired coupling products. The synthetic utility of this protocol was demonstrated through the transformation of resulting product to other ArSCF2-substituted alkynes and alkenes.

Fluorodecarboxylation: Synthesis of aryl trifluoromethyl ethers (ArOCF3) and thioethers (ArSCF3)

Fluorodecarboxylation of aryloxydifluoroacetic acid (ArOCF2CO2H) and arylmercaptodifluoroacetic acid (ArSCF2CO2H) towards ArXCF3 (X = O, S) using silver (I) salts in the presence of Selectfluor in a biphasic system with trifluoroacetic acid additive is discussed.

A convergent route to geminal difluorosulfides and to functionalized difluorothiochromans, a new family of organofluorine compounds

The synthesis of the novel O-ethyl-S-(4-chlorophenylthio)difluoromethyl xanthate and its radical addition to various terminal alkenes are described. The geminal difluorosulfide adducts undergo closure onto the aromatic ring by further treatment with perox