165059-97-2Relevant academic research and scientific papers
Synthesis of Terminal N-Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon
Nie, Zhiwen,Lv, Huifang,Li, Hui,Su, Miaodong,Yang, Tonglin,Luo, Weiping,Liu, Qiang,Guo, Cancheng
, p. 4621 - 4626 (2021/09/02)
A protocol for the synthesis of terminal N-vinylazoles from aromatic aldehydes, DMSO, and azoles has been reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and give the corresponding terminal N-vinylazoles in 52–91% yields. Based on preliminary experiments, a plausible mechanism is proposed. (Figure presented.).
A general copper-catalyzed coupling of azoles with vinyl bromides
Liao, Qian,Wang, Yuxing,Zhang, Liyun,Xi, Chanjuan
scheme or table, p. 6371 - 6373 (2009/12/08)
(Chemical Equation Presented) A copper-catalyzed methodology for the coupling of vinyl bromides with azoles has been developed. This protocol uses a combination of 10 mol % of copper iodide and 20 mol % of ethylenediamine as catalyst. The reaction proceed
Regioselective α-Arylation of N-Vinylpyrroles by the Heck Reaction
Shmidt,Vladimirova,Dmitrieva,Zinchenko
, p. 1497 - 1500 (2007/10/03)
A number of N-vinylpyrroles were arylated for the first time with aryl iodides in the presence of palladium compounds. N-Vinylpyrroles are thus smoothly converted into the corresponding N-arylethenyl derivatives. The regioselectivity of substitution at th
Methylenation of N-Acylheterocycles
Wattanasin, S.,Kathawala, F. G.
, p. 2659 - 2664 (2007/10/02)
Various N-alkenyl heterocycles can be obtained in modest to good yields by methylenation of N-acylheterocycles with the Tebbe reagent.The reaction provides a useful method for introducing the isopropyl group on the nitrogen of aromatic heterocycles.
