165065-03-2Relevant articles and documents
Synthesis and Biological Evaluation of Paclitaxel Analogs Modified in Ring C
Liang, Xian,Kingston, David G. I.,Lin, Chii M.,Hamel, Ernest
, p. 2901 - 2904 (1995)
Both 7-deoxy-7α-azidopaclitaxel (6) and 7-deoxy-Δ6,7-paclitaxel (4) can be prepared from paclitaxel-7-O-triflate (2b).Oxidation of 7-deoxy-Δ6,7-paclitaxel with dioxirane yields the epoxide 7, while oxidation with osmium tetroxide yie
Synthesis and Molecular Modeling of Taxanes Modified at Ring C
Menichincheri, Maria,Botta, Maurizio,Ceccarelli, Walter,Ciomei, Marina,Corelli, Federico,et al.
, p. 534 - 556 (2007/10/03)
Some new paclitaxel analogs, modified at ring C, - namely the 7-α-mesylate, 7-deoxy-7-α-amino, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco and 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco derivatives - are presented. The biological activity of 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-α-azido, 7-deoxy-7-α-amino and 6,7-epoxy derivatives heve been evaluated. A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.