165065-03-2

Upstream product

• 148930-54-5 (2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate 
• 33069-62-4 taxol 
• 171781-02-5 C₄₈H₅₀F₃NO₁₆S 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Paclitaxel Analogs Modified in Ring C

Both 7-deoxy-7α-azidopaclitaxel (6) and 7-deoxy-Δ6,7-paclitaxel (4) can be prepared from paclitaxel-7-O-triflate (2b).Oxidation of 7-deoxy-Δ6,7-paclitaxel with dioxirane yields the epoxide 7, while oxidation with osmium tetroxide yie

Synthesis and Molecular Modeling of Taxanes Modified at Ring C

Some new paclitaxel analogs, modified at ring C, - namely the 7-α-mesylate, 7-deoxy-7-α-amino, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco and 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco derivatives - are presented. The biological activity of 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-Δ6,7-20-O-seco, 4-deacetoxy-4α-hydroxy-4β-hydroxymethyl-5α-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-α-azido, 7-deoxy-7-α-amino and 6,7-epoxy derivatives heve been evaluated. A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity.