165069-47-6Relevant articles and documents
Variation of the Alkyl Side Chain in Δ8-THC
Huffman, John W.,Lainton, Julia A. H.,Dai, Dong,Jordan, Robert D.,Duncan, Sammy G.
, p. 2021 - 2024 (1995)
The synthesis of (2'RS)-2'-methyl-, (3'RS)-, (3'S)-3'-methyl-, and 4'-methyl-Δ8-THC has been carried out, and the pharmacology of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2'-methyl compound is somewhat more active than Δ8-THC, while the 4'-methyl isomer is less active. The 3'-methyl-Δ8-THC has approximately the same activity as the parent cannabinoid.