10422-35-2

Usage

Uses

1. Used in Chemical Synthesis:
1-Bromo-2-methylbutane is used as a reactant for the preparation of chiral diazenes, which are important intermediates in the synthesis of various pharmaceuticals and agrochemicals. Its unique structural features make it a valuable building block in the creation of complex organic molecules.
2. Used in Solar Cell Technology:
1-Bromo-2-methylbutane is also utilized in the synthesis of high-performance solar cell copolymers. These copolymers are designed to improve the efficiency and stability of solar cells by enhancing their light absorption and charge transport properties.
3. Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Bromo-2-methylbutane is used as a key intermediate in the synthesis of various drugs, particularly those targeting the central nervous system and other therapeutic areas.
4. Used in Agrochemical Industry:
1-Bromo-2-methylbutane is employed as a starting material for the development of new agrochemicals, such as pesticides and herbicides, due to its reactivity and ability to form a wide range of derivatives.
5. Used in Research and Development:
In the field of research and development, 1-Bromo-2-methylbutane is a valuable compound for exploring new reaction pathways and developing innovative synthetic methods, contributing to the advancement of organic chemistry and material science.

InChI:InChI=1/C5H11Br/c1-3-5(2)4-6/h5H,3-4H2,1-2H3

Upstream product

• 10035-10-6 hydrogen bromide 
• 563-46-2 2-Methyl-1-butene 
• 137-32-6 (+/-)-2-methyl-1-butanol 
• 7664-93-9 sulfuric acid 
• 1565-80-6 (2S)-2-methyl-1-butanol 
• 137-32-6 (-)-2-Methylbutan-1-ol 
• 63526-71-6 p-toluenesulfonic acid 2-methylbutyl ester 
• 116-53-0 2-Methylbutanoic acid 
• 78-78-4 methylbutane 
• 75-85-4 tert-Amyl alcohol 
• 507-36-8 2-bromo-2-methylbutane 
• 2049-70-9 diethyl 2-ethyl-2-methylmalonate 
• 7452-79-1 ethyl 2-methylbutyrate 

Downstream Products

• 59472-05-8 N-(2-methylbutyl)aniline 
• 58257-21-9 2-methylbutyltriphenylphosphonium bromide 
• 80699-59-8 3,7,11-trimethyl-10-dodecen-5-ol 
• 855923-68-1 1-Bromo-14-methylhexadecane 
• 111045-01-3 10-Keto-12-methyltetradecansaeuremethylester 
• 151554-98-2 (E)-4,8-dimethyl-4-decen-1-ol 
• 86414-50-8 (+/-)-3,7-dimethylnonan-1-ol 
• 62184-27-4 3,5,7-Trimethylnonane 
• 117952-74-6 (4R,8R)-4,8-dimethyldecan-1-ol 
• 87118-42-1 (4R,8S)-4,8-dimethyl-1-decanol 
• 85880-35-9 (4R,8R)-(-)-4,8-Dimethyldecanal 
• 85880-37-1 (4R,8S)-(+)-4,8-Dimethyldecanal 
• 87106-31-8 (4R,8R)-4,8-dimethyldecanenitrile 
• 87106-35-2 (4R,8S)-(+)-4,8-dimethyldecanenitrile 

Relevant academic research and scientific papers

5. Novel alkaloids from the poison glands of ants Leptothoracini

Novel pyrrolidine alkaloids were isolated from the poison glands of ants Leptothoracini (Myrmicinae) and identified as a mixture of N-alkylated 3-methylpyrrolidines. The females of these species produce male-attracting pheromones in their poison glands. The basic compounds in the secretions were found to be active. The major alkaloid, 3-methyl-1-(3-methylbutyl)pyrrolidine (5), is present in only ng quantities per gland.

Synthesis and mass spectra of rearrangement bio-signature metabolites of anaerobic alkane degradation via fumarate addition

Metabolite profiling in anaerobic alkane biodegradation plays an important role in revealing activation mechanisms. Apart from alkylsuccinates, which are considered to be the usual biomarkers via fumarate addition, the downstream metabolites of C-skeleton rearrangement can also be regarded as biomarkers. However, it is difficult to detect intermediate metabolites in both environmental samples and enrichment cultures, resulting in lacking direct evidence to prove the occurrence of fumarate addition pathway. In this work, a synthetic method of rearrangement metabolites was established. Four compounds, namely, propylmalonic acid, 2-(2-methylbutyl)malonic acid, 2-(2-methylpentyl)malonic acid and 2-(2-methyloctyl)malonic acid, were synthesized and determined by four derivatization approaches. Besides, their mass spectra were obtained. Four characteristic ions were observed at m/z 133 + 14n, 160 + 28n, 173 + 28n and [M - (45 + 14n)]+ (n = 0 and 2 for ethyl and n-butyl esters, respectively). For methyl esterification, mass spectral features were m/z 132, 145 and [M - 31]+, while for silylation, fragments were m/z 73, 147, 217, 248, 261 and [M - 15]+. These data provide basis on identification of potential rearrangement metabolites in anaerobic alkane biodegradation via fumarate addition.

New syntheses of 1,7-dimethylnonyl propanoate, the western corn rootworm pheromone, in four different ways via cross metathesis, alkylation and coupling reactionsss

A mixture of the four stereoisomers of 1,7-dimethylnonyl propanoate, the female sex pheromone of the western corn rootworm (Diabrotica virgifera virgifera LeConte), was synthesized in four different ways by employing one of the following four reactions as the key step: (i) cross metathesis using the Grubbs I catalyst, (ii) cross metathesis using the Grubbs II catalyst, (iii) alkylation of an alkynide anion, and (iv) Grignard coupling in the presence of dilithium tetrachlorocuprate. Although the cross metathesis approaches enabled two short syntheses (4 or 6 steps) of the pheromone to be achieved, the cheapest and most efficient synthesis was possible via Grignard coupling to give the desired pheromone in a 40% overall yield based on 2-methyl-1-butanol (8 steps).

Photochromic glassy liquid crystals comprising mesogenic pendants to dithienylethene cores

Photochromic glassy liquid crystals were synthesized using dithienylethenes as the volume-excluding cores to which liquid crystalline mesogens were chemically bonded through alkyl spacers. Nematic, smectic, and cholesteric glassy liquid crystals were demonstrated with glass transition temperatures above 90 °C and clearing points up to 220 °C without traces of crystallization on cooling or crystalline melting on heating. A monodomain cholesteric glassy liquid crystalline film containing an enantiomeric 2-methylpropylene chiral spacer was characterized as a left-handed helical stack, exhibiting a selective reflection band centered at 686 nm, an orientational order parameter of 0.65 for the quasi-nematic layers, and a combination of reflective coloration with photoswitchable absorptive coloration.

Identification and assignment of the absolute configuration of biologically active methyl-branched ketones from limnephilid caddis flies

Glands of the 4th and 5th abdominal stemite of the caddis flies Potamophylax latipennis, Potamophylax cingulatus, and Glyphotaelius pellucidus contain (S)-4-methyl-3-heptanone (4a), (4S,6S)-4,6-dimethyl-3-octanone (4b), and (4S,6S)-4,6-dimethyl-3-nonanone (4c). As shown by gas chromatography coupled with electrophysiological recordings, these ketones elicit a strong response in the insects' antennae. The structural assignment of the compounds was achieved on the basis of mass spectra, enantioselective synthesis, and gas chromatography on a chiral stationary phase.

Synthesis and biological activity of methyl 2,6,10-trimethyldodecanoate and methyl 2,6,10-trimethyltridecanoate: Male-produced sexual pheromones of stink bugs Euschistus heros and Piezodorus guildinii

Methyl 2,6,10-trimethyltridecanoate (1) and methyl 2,6,10-trimethyldodecanoate (2) have been identified as male-produced sex pheromones of the Brazilian soybean stink bugs Euschistus heros (F.) and Piezodorus guildinii (Westwood). In order to establish a defined attractive blend for both species, compounds 1 and 2 were synthesized as mixtures of stereoisomers to be employed in behavior bioassays. (±)-Citronellol (3) was utilized as starting material, and the syntheses was carried out in six steps with good overall yield. When tested alone, synthetic compounds 1 and 2 proved to be active in a two-choice olfactometer; however, a 20: 1 mixture of 1 and 2 was much more attractive to E. heros females. A similar blend had been found among the headspace volatiles of males.

Esterification of carboxylic acid salts

Mono- or polycarboxylic acid esters are prepared by reacting a salt of such carboxylic acid with an organic halocompound, e.g., a (cyclo)alkyl, (cyclo)alkenyl, aryl or aralkyl halide, in an aqueous reaction medium, in the presence of a catalytically effective amount of a phase transfer catalyst, for example an onium salt.

Hair cosmetic composition

A hair cosmetic composition comprising a branched fatty acids of the following formula (1), STR1 wherein R1 is a methyl or ethyl group, n is an integer of 4-16, and R2 is an amino, alkoxy, or glycerol group. The composition imparts excellent sensation to hair and prevents hairs from being damaged.

Variation of the Alkyl Side Chain in Δ8-THC

The synthesis of (2'RS)-2'-methyl-, (3'RS)-, (3'S)-3'-methyl-, and 4'-methyl-Δ8-THC has been carried out, and the pharmacology of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2'-methyl compound is somewhat more active than Δ8-THC, while the 4'-methyl isomer is less active. The 3'-methyl-Δ8-THC has approximately the same activity as the parent cannabinoid.

Pheromones, 89.- Wittig Syntheses of Alkyl-Branched and Cyclic Analogs of (Z)-5-Decenyl Acetate, the Sex Pheromone of Agrotis segetum (Lepitoptera: Noctuidae)

By means of (Z)-selective Wittig olefination alkyl-branched and cyclic analogs of (Z)-5-decenyl acetate, the sex pheromone of the turnip moth, Agrotis segetum (Lepidoptera: Noctuidae), have been synthesized. Key Words: Pheromones / (Z)-5-decenyl acetate / Wittig reactions / Agrotis segetum