165115-83-3 Usage
Uses
Used in Pharmaceutical Industry:
1H-1,2,4-Triazole, 1-[[2-(2,4-difluorophenyl)tetrahydro-4-[(phenylmethoxy)methyl]-2-furanyl]methyl]-, (2R-cis)(9CI) is used as an impurity in Posaconazole (P689600), an orally active triazole antifungal agent. Posaconazole is utilized for the treatment of various fungal infections, including invasive aspergillosis, candidiasis, and other systemic mycoses. The presence of 1H-1,2,4-Triazole, 1-[[2-(2,4-difluorophenyl)tetrahydro-4-[(phenylmethoxy)methyl]-2-furanyl]methyl]-, (2R-cis)- (9CI) as an impurity in Posaconazole highlights the importance of monitoring and controlling the quality of pharmaceutical products to ensure their safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 165115-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,1,1 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 165115-83:
(8*1)+(7*6)+(6*5)+(5*1)+(4*1)+(3*5)+(2*8)+(1*3)=123
123 % 10 = 3
So 165115-83-3 is a valid CAS Registry Number.
165115-83-3Relevant academic research and scientific papers
Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals Sch 51048 and Sch 56592
Saksena, Anil K.,Girijavallabhan, Viyyoor M.,Wang, Haiyan,Liu, Yi-Tsung,Pike, Russell E.,Ganguly, Ashit K.
, p. 5657 - 5660 (2007/10/03)
Two complimentary approaches to the key (-)-(2R)-cis-tosylate 1 and its (+)-(2S)-enantiomer 15 via generation of chiral imide enolates having a 2,2-disubstituted olefin functionality in the β-position, are described. In a 'protecting group free' sequence, reaction of the titanium enolate generated from (4R)-benzyl-2-oxazolidinone derived imide 5b with s-trioxane provided a convenient intermediate 19 which could be directly subjected to 2,4-diastereoselective iodocyclization.
