165258-33-3

Upstream product

• 31456-95-8 Methyl 4-methoxy-2-(prop-2-enyloxy)benzoate 
• 165258-22-0 N,N-Diethyl-5-bromo-2-<(tert-butyldimethylsilyl)oxy>-4-methoxy-3-(prop-2-enyl)benzamide 
• 165258-21-9 N,N-Diethyl-5-bromo-2-hydroxy-4-methoxy-3-(prop-2-enyl)benzamide 
• 165258-20-8 N,N-Diethyl-2-hydroxy-4-methoxy-3-(prop-2-enyl)benzamide 
• 165258-18-4 N,N-Diethyl-4-methoxy-2-(prop-2-enyloxy)benzamide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 5446-02-6 4-methoxymethylsalicylate 

Downstream Products

• 165258-34-4 N,N-Diethyl-2-<(tert-butyldimethylsilyl)oxy>-6-hydroxymethyl-4-methoxy-5-methyl-3-(prop-2-enyl)benzamide 

Relevant academic research and scientific papers

The Synthesis of Mycophenolic Acid from 2,4-Dihydroxybenzoic Acid

Mycophenolic acid (1) has been synthesized from 2,4-dihydroxybenzoic acid by regioselective introduction of the three required carbon substituents.A key transformation in this sequence is the introduction of the methyl substituent at position 5 by a rapid, uncatalyzed replacement of the bromide in 8 at low temperature by methyllithium.The scope and mechanism of this methylation reaction are examined.