165280-21-7

Basic information

• Product Name: Benzenamine, 4-nitro-2-(phenylethynyl)-
• CAS NO: 165280-21-7
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• Mol File: 165280-21-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-nitro-2-(phenylethynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-nitro-2-(phenylethynyl)-(165280-21-7)
• EPA Substance Registry System: Benzenamine, 4-nitro-2-(phenylethynyl)-(165280-21-7)

Safety Data

• Hazardous Substances Data: 165280-21-7(Hazardous Substances Data)

Upstream product

• 6293-83-0 2-iodo-4-nitrophenylamine 
• 536-74-3 phenylacetylene 
• 100-01-6 4-nitro-aniline 
• 125600-42-2 2-amino-5-nitrophenylacetylene 
• 591-50-4 iodobenzene 
• 13296-94-1 2-bromo-4-nitroaniline 

Downstream Products

• 1313215-30-3 1-azido-4-nitro-2-(phenylethynyl)benzene 
• 1632138-03-4 C₂₂H₂₀N₂O₆ 
• 1428020-43-2 4-(5-nitro-2-phenyl-1H-indol-3-yl)butan-2-one 
• 6855-64-7 2-phenyl-1H-indol-5-amine 
• 1208105-25-2 C₁₇H₁₄N₂O₃ 
• 500992-02-9 N-[(4'-nitro-2'-phenylethynyl)phenyl]butyramide 
• 4993-87-7 5-nitro-2-phenyl-1H-indole 

Relevant articles and documents

Copper-Catalyzed Aerobic Oxidative Cyclization of 2-Alkynylanilines with Nitrosoarenes: Synthesis of Organic Solid Mechanoluminescence Compounds of 4-Oxo-4 H-cinnolin-2-ium-1-ide

An efficient Cu(I)/DMAP/air system for the one-pot synthesis of 4-oxo-4H-cinnolin-2-ium-1-ides, which are often difficult to prepare by traditional routes from substituted 2-alkynylanilines and nitrosoarenes, was developed. These 4-oxo-4H-cinnolin-2-ium-1-ides have practical applications as mechanoluminescent materials. Preliminary mechanistic experiments were performed, and a plausible mechanism for this tandem process is proposed. The use of an inexpensive copper catalyst and molecular oxygen as the oxygen source and the oxidant make this an attractive green protocol with potential synthetic applications.

Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides

Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive molecules. The synthesis and biological evaluation of the compounds combining these two scaffolds have rarely been reported. Herein, we repot the first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1′-indolyl)-phthalides (42 examples, up to 96% yield) under mild conditions. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogues.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.