165286-08-8

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 20939-15-5 3-methyl-4-amino-5-mercapto-1,2,4-triazole 
• 20939-15-5 4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione 

Relevant academic research and scientific papers

Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1,2,4-triazole Schiff base

A series of novel myricetin derivatives containing a 1,2,4-triazole Schiff base were designed and synthesized. Their structures were systematically characterized using 1H NMR, 13C NMR, and HRMS. During antibacterial bioassays, 6f, 6i, and 6q demonstrated a good inhibitory effect against Xanthomonas axonopodis pv. citri (Xac), with half-maximal effective concentration (EC50) values of 10.0, 9.4, and 8.8 μg mL-1, respectively, which were better than those of bismerthiazol (54.9 μg mL-1) and thiodiazole copper (61.1 μg mL-1). Note that 6w demonstrated a good inhibitory effect against Ralstonia solanacearum (Rs) with and EC50 value of 15.5 μg mL-1, which was better than those of bismerthiazol (55.2 μg mL-1) and thiodiazole copper (127.9 μg mL-1). Similarly, 6a, 6d, and 6e demonstrated a good inhibitory effect against Xanthomonas oryzae pv. oryzae (Xoo) with EC50 values of 47.1, 61.2, and 61.0 μg mL-1, respectively, which were better than those of bismerthiazol (148.2 μg mL-1) and thiodiazole copper (175.5 μg mL-1). Furthermore, we used scanning electron microscopy (SEM) to study the possible sterilization process of the target compound 6q against Xac. The results indicated the possibility of destroying the bacterial cell membrane structure, resulting in an incomplete bacterial structure, and thus achieving inhibition. Furthermore, antiviral bioassays revealed that most compounds exhibited excellent antiviral activity against tobacco mosaic virus (TMV) at a concentration of 500 μg mL-1. The results of the molecular docking studies for 6g with TMV-CP (PDB code: 1EI7) showed that compound 6g had partially interacted with TMV-CP. Therefore, mechanistic studies of the action of compound 6g could be further studied based on that.

Synthesis of Schiff and Mannich bases of news-triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and as antimicrobial agents

An efficient, simple, and one-pot double Mannich reaction was performed for the synthesis of cyclized 2-methyl-6-substituted-6,7-dihydro-5H-s-triazolo[5,1-b]-1,3,5-thiadiazinesviaa reaction of 5-methyl-1H-s-triazole-3-thiol (1) with formaldehyde and prima

Liquid-liquid extraction of metal ions, DFT and TD-DFT analysis of some 1,2,4-triazole Schiff Bases with high selectivity for Pb(II) and Fe(II)

Liquid-liquid extraction of metal ions using some 1,2,4-triazole Schiff base derivatives as new extractants was studied. Fe2+, Zn2+, Cu2+, Co2+, Cd2+ and Pb2+ were extracted from the aqueou

Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold

APOBEC3G (A3G) is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. Although A3G can potently restrict Vif-deficient HIV-1 replication by catalyzing excessive levels of G→A hypermutation,

Extraction and separation studies of rhodium(III) with 4-(4- methoxybenzylideneamino)-5-methyl-4H-1,2,4-triazole-3-thiol in hydrochloric acid medium

A novel method is proposed for the extraction of microgram level concentration of rhodium(III) from hydrochloric acid medium with 4-(4-methoxybenzylideneamino)-5-methyl-4H-l,2,4-triazole-3-thiol (MBIMTT) dissolved in chloroform as an extractant. It was stripped from organic phase with 1 M hydrochloric acid and estimated spectrophoto-metrically with stannous chloride. The effect of acid concentration and various foreign ions has been investigated. The method is applicable to the analysis of synthetic mixtures. The method is highly selective, simple and reproducible.