165377-43-5

Usage

Uses

Used in Psychotherapy:
1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE is used as a therapeutic agent for its potential to enhance psychotherapy sessions. It is believed to facilitate introspection and emotional processing, which can contribute to the treatment of various mental health conditions.
Used in Research on Central Nervous System:
In the field of neuroscience, 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE is used as a research tool to study the effects of serotonin receptor agonists on the central nervous system. This helps scientists to better understand the mechanisms of action and potential therapeutic applications of similar compounds.
Note: It is important to mention that the use and distribution of 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE are illegal and strictly regulated in many countries due to its potential for abuse and harmful effects on health.

Upstream product

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• 55455-92-0 1-(3-phenylpropyl)piperazine 
• 40173-90-8 3,4-dimethoxyphenethyl bromide 
• 165377-44-6 Cutamesine dihydrochloride 
• 4247-65-8 N,N-bis(2-hydroxyethyl)-2-<(3,4-dimethoxy)phenyl>ethylamine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 621-79-4 cinnamamide 

Relevant academic research and scientific papers

Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging

A series of spirocyclic piperidine derivatives were designed and synthesized as σ1 receptor ligands. In vitro competition binding assays showed that 1′-(4-(2-fluoroethoxy)benzyl)-3H-spiro[2- benzofuran-1,4′-piperidine] (19) possessed high σ1 receptor affinity (Ki = 0.79 nM) and excellent σ1/ σ2 subtype selectivity (350-fold) as well as high σ1/VAChT selectivity (799-fold). The radiolabeled compound [18F]19 was synthesized by substitution of the tosylate precursor 24 with [18F]fluoride, with an isolated radiochemical yield of 35-60%, a radiochemical purity of >99%, and a specific activity of 30-55 GBq/μmol. Biodistribution studies in imprinting control region mice indicated that [ 18F]19 displayed excellent initial brain uptake and slow washout. Ex vivo autoradiography in Sprague-Dawley rats demonstrated high accumulation of the radiotracer in brain areas known to express high levels of σ1 receptors. Micro positron emission tomography imaging and blocking studies confirmed the specific binding of [18F]19 to σ1 receptors in vivo.

PIPERAZINE DERIVATIVES

Compounds of general formula (I) in which R1 and R0 have any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.

Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines

A set of the title compounds having different substituents (R1, R2) on their phenyl groups was synthesized to find σ receptor binding affinity. Among the compounds, 2b (R1=R2=Cl) has the most potent σ1-binding activity, while 2a (R1=R2=H, SA4503) was most selective to σ1 over σ2 receptor. The crystal structures of 2a and 2b were shown, by X-ray crystallography, to be similar except for the one torsional angle of their propylene parts. Quantitative structure-activity relationship study suggested the affinity of the compounds to the σ1 receptor was dependent on the electronic feature, Swain-Lupton's R or S(π) that was derived by molecular orbital method, of R1 and R2.