4247-65-8Relevant academic research and scientific papers
1,4-(diphenlyalkyl) piperazine derivatives
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, (2008/06/13)
This invention relates to novel compounds of the formula [I], STR1 wherein R 1 and R 2 are the same or different and each represents a lower alkoxy group; A and B are the same or different and each represents a lower alkylene group.The compounds of this i
Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines
Fujimura, Ken-Ichi,Matsumoto, Junzo,Niwa, Masashi,Kobayashi, Tadayuki,Kawashima, Yoichi,In, Yasuko,Ishida, Toshimasa
, p. 1675 - 1683 (2007/10/03)
A set of the title compounds having different substituents (R1, R2) on their phenyl groups was synthesized to find σ receptor binding affinity. Among the compounds, 2b (R1=R2=Cl) has the most potent σ1-binding activity, while 2a (R1=R2=H, SA4503) was most selective to σ1 over σ2 receptor. The crystal structures of 2a and 2b were shown, by X-ray crystallography, to be similar except for the one torsional angle of their propylene parts. Quantitative structure-activity relationship study suggested the affinity of the compounds to the σ1 receptor was dependent on the electronic feature, Swain-Lupton's R or S(π) that was derived by molecular orbital method, of R1 and R2.
Agent for treatment of disorders of the cerebro-neural transmission system
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, (2008/06/13)
A method for treatment of disorders of the cerebro-neural transmission system which comprises administering a compound of the formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically effective amount, either alone or in admixture wit
