16538-84-4Relevant academic research and scientific papers
Expeditious Synthesis of Functionalized 1-Arylcyclooctadienes via Palladium-Catalyzed Lithium Cross-Coupling
Wandler, Angela E. E.,Br?se, Stefan
, p. 4125 - 4128 (2016)
The palladium-catalyzed direct cross-coupling of aryl bromides and (1Z,5Z)-cycloocta-1,5-dien-1-yllithium is described as an important method to synthesize 1-arylcyclooctadienes. The use of a well-established Pd2dba3/XPhos catalytic system affords the desired new compounds in good to excellent yields; the reaction proceeds at room temperature with both high efficiency and selectivity. Finally we found the best conditions to combine a suitable lithium-halogen exchange with a cross-coupling reaction. (Figure presented.).
