165403-06-5Relevant academic research and scientific papers
Total synthesis of (+)-laurencin. Use of acetal-vinyl sulfide cyclizations for forming highly functionalized eight-membered cyclic ethers
Bratz, Matthias,Bullock, William H.,Overman, Larry E.,Takemoto, Tadahiro
, p. 5958 - 5965 (2007/10/02)
The enantioselective total synthesis of (+)-laurencin (1) is accomplished in 24 steps from allyl alcohol. The synthesis features an acetal-vinyl sulfide cyclization that forms the oxocene ring and introduces, with complete control, the Δ4 unsat
