165459-69-8

Basic information

• Product Name: (3,5-dimethoxyphenyl)isonitrile
• Synonyms: (3,5-dimethoxyphenyl)isonitrile
• CAS NO: 165459-69-8
• Molecular Weight: 163.176
• Mol File: 165459-69-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (3,5-dimethoxyphenyl)isonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-dimethoxyphenyl)isonitrile(165459-69-8)
• EPA Substance Registry System: (3,5-dimethoxyphenyl)isonitrile(165459-69-8)

Safety Data

• Hazardous Substances Data: 165459-69-8(Hazardous Substances Data)

Upstream product

• 34967-25-4 3,5-dimethoxybenzaldoxime 
• 10272-07-8 3.5-dimethoxyaniline 
• 1353562-24-9 N-(3,5-dimethoxyphenyl)formamide 
• 67-66-3 chloroform 

Downstream Products

• 79257-61-7 N-(3,5-dimethoxy-phenyl)-acetamide 

Relevant articles and documents

A convenient reagent for the conversion of aldoximes into nitriles and isonitriles

For the dehydroxylation of aldoximes with 4-nitro-1-((trifluoromethyl)sulfonyl)-imidazole (NTSI), slight modifications of reaction conditions resulted in significantly different reaction paths to provide either nitriles or isonitriles. The challenging conversion of aldoximes into isonitriles was achieved under mild conditions.

Aerobic radical-cascade cycloaddition of isocyanides, selenium and imidamides: Facile access to 1,2,4-selenadiazoles under metal-free conditions

A novel and facile metal-free method for the green synthesis of 1,2,4-selenadiazol-5-amine derivatives through the aerobic radical-cascade multi-component reactions of isocyanides, selenium powder and imidamides is reported herein. O2 in the air was employed as the green oxidant to achieve the cycloaddition with the generation of H2O as the sole by-product. It also features good functional group compatibility and broad substrate scope. In addition, this method was successfully applied to the functionalization of biologically active molecules.

A novel method for preparing isocyanides from N-substituted formamides with chlorophosphate compounds

Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl2, EtOPOCl2, Me2NPOCl2, and (PhO)2POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. Georg Thieme Verlag Stuttgart · New York.