16552-98-0Relevant academic research and scientific papers
Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands
Deng, Jungang,Yu, Ping,Zhang, Zhenlei,Wang, Jun,Cai, Jinhua,Wu, Na,Sun, Hongbin,Liang, Hong,Yang, Feng
, p. 442 - 452 (2018)
To develop potential next-generation metal anticancer agents, we designed and synthesised five Cu(II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen atom at the N-4 position of ligands, and then investigated their structure-activity rela
Novel 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle
Qi, Jinxu,Deng, Jungang,Qian, Kun,Tian, Liang,Li, Jiaming,He, Kunhuan,Huang, Xueren,Cheng, Zhen,Zheng, Yunyun,Wang, Yihong
, p. 34 - 42 (2017)
Two types of 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes, which are 2:1 and 1:1 ligand/Ga(III) complexes, were synthesized and determined by X-ray single crystal diffraction. The antiproliferative activity of these Ga(III) complexes have
Developing a Novel Indium(III) Agent Based on Liposomes to Overcome Cisplatin-Induced Resistance in Breast Cancer by Multitargeting the Tumor Microenvironment Components
Chu, Yong,Jiang, Ming,Li, Wenjuan,Liang, Hong,Sun, Hongbin,Yang, Feng,Yang, Tongfu,Zhang, Zhenlei
, p. 14587 - 14602 (2021/10/25)
To overcome the resistance of cancer cells to platinum-based drugs and effectively suppress tumor growth, we developed a novel indium (In) agent based on liposomes (Lips). Thus, we not only obtained an In(III) thiosemicarbazone agent (5b) with remarkable
Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex
Li, Wenjuan,Liang, Hong,Pang, Min,Sun, Hongbin,Wang, Xiaojun,Wu, Junmiao,Yang, Feng,Yang, Tongfu
, p. 10909 - 10921 (2021/08/17)
In this study, we proposed to design effective multi-target anticancer agents based on the chelation of nontoxic metals with ligands that possess anticancer activity. In total, five Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complexes are synthesi
Tin complex with 2-pyridineformaldehyde thiosemicarbazone as ligand and synthesis method thereof
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Paragraph 0044-0047, (2020/02/14)
The invention discloses a tin complex taking 2-pyridineformaldehyde thiosemicarbazone as a ligand and a synthesis method thereof. The synthesis method comprises the following steps of: dissolving thiosemicarbazone in anhydrous CH3OH, adding 2-pyridineform
FTO small molecule inhibitor palladium complex and synthesis method thereof
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Paragraph 0009; 0040-0043, (2020/11/26)
The invention discloses an FTO small molecule inhibitor palladium complex and a synthesis method thereof. The synthesis method comprises the following steps: dissolving thiosemicarbazide in anhydrousCH3OH, then adding 2-pyridylaldehyde, carrying out reflu
Indium compound taking 2-pyridylaldehyde thiosemicarbazone as ligand as well as synthesis method and application thereof
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Paragraph 0049-0052, (2019/06/12)
The invention discloses an indium compound taking 2-pyridylaldehyde thiosemicarbazone as a ligand as well as a synthesis method and application thereof. The synthesis method comprises the following steps: dissolving thiosemicarbazide into methanol; after
Platinum complex taking 2-pyridine formaldehyde thiosemicarbazone as ligand and synthesis method and application thereof
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Paragraph 0047-0050, (2019/07/01)
The invention discloses a platinum complex taking 2-pyridine formaldehyde thiosemicarbazone as ligand and a synthesis method and application thereof. The synthesis method includes: dissolving thiosemicarbazone in methanol, adding 2-pyridylaldehyde after d
Impact of metal coordination on cytotoxicity of 3-aminopyridine-2- carboxaldehyde thiosemicarbazone (Triapine) and novel insights into terminal dimethylation
Kowol, Christian R.,Trondl, Robert,Heffeter, Petra,Arion, Vladimir B.,Jakupec, Michael A.,Roller, Alexander,Galanski, Markus,Berger, Walter,Keppler, Bernhard K.
experimental part, p. 5032 - 5043 (2010/03/02)
The first metal complexes of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine) were synthesized. Triapine was prepared by a novel three-step procedure in 64% overall yield. In addition, a series of related ligands, namely, 2-formylpyridine thiosemicarbazone, 2-acetylpyridine thiosemicarbazone, 2-pyridineformamide thiosemicarbazone, and their N 4-dimethylated derivatives (including the N4-dimethylated analogue of Triapine) were prepared, along with their corresponding gallium(III) and iron(III) complexes with the general formula [M(L)2] +, where HL is the respective thiosemicarbazone. The compounds were characterized by elemental analysis, 1H and 13C NMR, IR and UV-vis spectroscopies, mass spectrometry, and cyclic voltammetry. In addition, Triapine and its iron(III) and gallium(III) complexes were studied by X-ray crystallography. All ligands and complexes were tested for their in vitro antiproliferative activity in two human cancer cell lines (41M and SK-BR-3), and structure-activity relationships were established. In general, the coordination to gallium(III) increased the cytotoxicity while the iron(III) complexes show reduced cytotoxic activity compared to the metal-free thiosemicarbazones. Selected compounds were investigated for the capacity of inhibiting ribonucleotide reductase by incorporation of 3H-cytidine into DNA.
