16554-53-3

Upstream product

• 288-32-4 1H-imidazole 
• 4532-02-9 diethyl (2-nitrophenyl) phosphate 
• 610-69-5 2-nitrophenyl acetate 
• 3229-70-7 phenolate 
• 14609-76-8 4-cyanophenolate 
• 18938-17-5 4-formylphenoxide ion 
• 2639-52-3 2-nitrophenyl dodecanoate 
• 22065-72-1 Cyanessigsaeure-o-nitrophenylester 
• 138554-71-9 2-nitrophenyl diphenylphosphate ester 
• 261172-44-5 4-acetylphenoxide 
• 88-75-5 2-hydroxynitrobenzene 
• 369-07-3 o-nitrophenyl-α-D-galactopyranoside 
• 2816-24-2 o-nitrophenyl D-galactopyranoside 

Downstream Products

• 288-32-4 1H-imidazole 
• 4532-02-9 diethyl (2-nitrophenyl) phosphate 
• 88-75-5 2-hydroxynitrobenzene 
• 4560-41-2 2-benzyloxynitrobenzene 
• 95-55-6 2-amino-phenol 

Relevant academic research and scientific papers

Supramolecular Interaction of Molecular Cage and β-Galactosidase: Application in Enzymatic Inhibition, Drug Delivery and Antimicrobial Activity

Enzyme inhibitors play a crucial role in diagnosis of a wide spectrum of diseases related to bacterial infections. We report here the effect of a water-soluble self-assembled PdII8 molecular cage towards β-galactosidase enzyme activity. The molecular cage is composed of a tetrapyridyl donor (L) and cis-[(en)Pd(NO3)2] (en=ethane-1,2-diamine) acceptor and it has a hydrophobic internal cavity. We have observed that the acceptor moiety mainly possesses the ability to inactivate the β-galactosidase enzyme activity. Kinetic investigation revealed the mixed mode of inhibition. This inhibition strategy was extended to control the growth of methicillin-resistant Staphylococcus aureus. The internalization of the Pd(II) cage inside the bacteria was confirmed when bacterial solutions were incubated with curcumin loaded cage. The intrinsic green fluorescence of curcumin made the bacteria glow when put under an optical microscope. Furthermore, this curcumin loaded molecular cage shows an enhanced antibacterial activity. Thus, PdII8 molecular cage is quite attractive due to its dual role as enzyme inhibitor and drug carrier.

A Simple but Efficient Catalytic Approach for the Degradation of Pollutants in Aqueous Media through Cicer arietinum Supported Ni Nanoparticles

Plant based materials are considered to have broad applications in the remediation of toxic materials. In this report, we present an environmental friendly and economic Cicer arietinum, named as (CP) supported for the synthesis of Ni nanoparticles (NPs) designated as Ni@CP. The in situ Ni@CP NPs were obtained using aqueous medium in the presence of sodium borohydride (NaBH4) as a reducing agent. The prepared catalysts were applied for the hydrogenation/degradation of p-nitrophenol (PNP), o-nitrophenol (ONP), and 2,4-dinitrophenol (DNP), as well as congo red (CR), methyl orange (MO), methylene blue (MB) and rhodamine B (RB) dyes. The amount of total metal ions adsorbed onto the CP was evaluated by flame atomic absorption spectroscopy. The Ni@CP catalyst was characterized through PXRD, FTIR, FESEM and EDX analyses.

High catalytic efficiency of nanostructured β-CoMoO4 in the reduction of the ortho-, meta- and para-nitrophenol isomers

Nanostructured -CoMoO4 catalysts have been prepared via the thermal decomposition of an oxalate precursor. The catalyst was characterized by infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), energy dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM). The efficiency of these nanoparticles in the reduction of ortho- and meta-nitrophenol isomers (2-NP, 3-NP, and 4-NP) to their corresponding aminophenols was tested using UV-visible spectroscopy measurements. It was found that, with a -CoMoO4 catalyst, NaBH4 reduces 3-NP instantaneously, whilst the reduction of 2-NP and 4-NP is slower at 8 min. This difference is thought to arise from the lower acidity of 3-NP, where the negative charge of the phenolate could not be delocalized onto the oxygen atoms of the meta-nitro group.

Biomimetic synthesis of silver nanoparticles using the fish scales of Labeo rohita and their application as catalysts for the reduction of aromatic nitro compounds

In this article, a cleaner, greener, cheaper and environment friendly method for the generation of self assembled silver nanoparticles (Ag NPs) applying a simple irradiation technique using the aqueous extract of the fish scales (which is considered as a waste material) of Labeo rohita is described. Gelatin is considered as the major ingredient responsible for the reduction as well as stabilisation of the self assembled Ag NPs. The size and morphology of the individual Ag NPs can be tuned by controlling the various reaction parameters, such as temperature, concentration, and pH. Studies showed that on increasing concentration and pH Ag NPs size decreases, while on increasing temperature, Ag NPs size increases. The present process does not need any external reducing agent, like sodium borohydride or hydrazine or others and gelatin itself can play a dual role: a 'reducing agent' and 'stabilisation agent' for the formation of gelatin-Ag NPs colloidal dispersion. The synthesized Ag NPs were characterised by Ultraviolet-Visible spectroscopy (UV-Vis), Transmission electron microscopy (TEM) and Selected area electron diffraction (SAED) analyses. The synthesized Ag NPs was used to study the catalytic reduction of various aromatic nitro compounds in aqueous and three different micellar media. The hydrophobic and electrostatic interaction between the micelle and the substrate is responsible for the catalytic activity of the nanoparticles in micelle.

Evaluating binuclear copper(II) complexes for glycoside hydrolysis

Three binuclear copper(II) complexes were characterized as solids by X-ray diffraction and in solution by UV/vis spectrophotometric titration, and subsequently evaluated for their glycosidase-like activity. The structure analysis revealed comparable intermetallic Cu ? ? ? Cu distances (~3.5 A) for the complexes 2 and 3. Despite this similarity, the composition of the complexes differs significantly in aqueous solution as revealed by spectrophotometric titrations. The hydrolysis of selected nitrophenylglycopyranosides is up to 11,000-fold accelerated over background in the presence of the copper(II) complexes in 3-(cyclohexylamino)-1- propanesulfonic acid (CAPS) buffer at pH 10.5 and 30 °C.

Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents

Recently, we described a new concept for the design of highly selective antiviral and anticancer chemotherapeutic agents that makes use of a disease-specific nucleic acid sequence to template the association of a prodrug with a catalyst which catalyzes th

Capillary Electrophoresis as a Method for Determining Binding Constants: Application to the Binding of Cyclodextrins and Nitrophenolates

For analytes involved in dynamic aquilibrium processes, capillary electrophoresis is a powerful method of determining binding constants.Equilibrium constants from capillary electrophoresis for the binding of nitrophenolates to α-cyclodextrin show good agreement with literature values obtained using calorimetric and spectroscopic methods, confirming capillary electrophoresis as a viable method.We show that it is imperative to make viscosity corrections, to study the full binding range, and to use an algorithm which calculates the concentration of free cyclodextrin rather than the total cyclodextrin concentration.Binding constants for analytes in a complex mixture can be determined simultaneously.The methods have been applied to 2-, 3-, and 4-nitrophenolates with native and derivatized α- and β-cyclodextrins, and results provide insight into the binding process.Data analysis methods for capillary electrophoresis are also successfully applied to liquid chromatography with the use of the same selector as mobile phase additive.

Kinetic method for the quantitative resolution of structural isomers based on the catalytic properties of β-cyclodextrin

This paper describes a new approach for the quantitative resolution of mixtues of structural isomers. The method is based on the observation that rate constants for the cyclodextrin-catalyzed hydrolysis of selected structural isomers are significantly dif

Dependence of Transition-state Structure on Nucleophile in the Reaction of Aryl Oxide Anions with Aryl Diphenylphosphate Esters

Second-order rate constants have been measured for reaction of aryl oxide anions with substituted phenyl diphenylphosphate esters in aqueous media at 25 deg C.The rate constants obey good Broensted type correlations with the pKa of either the leaving group or nucleophile.Both βnuc and βlg values vary substantially with basicity of leaving group and nucleophile, respectively, providing evidence for coupling between bond fission and formation.Attack of phenolate ions on 2,4-dinitrophenyl diphenylphosphate has a βnuc value of 0.12 giving a Kreevoy's tightness parameter value, τ, of 0.18 which is consistent with an 'exploded' transition state for the identity reaction involving 2,4-dinitrophenolate ion as the nucleophile.Transfer of the diphenylphosphinoyl group between 2,4-dinitrophenolate ion nucleophiles has a τ value of 0.28, consistent with an 'exploded' transition state for this reaction also.The identity reaction involving transfer of the diphenylphosphoryl group between phenolates ions has a τ value of 1.20, indicating an almost synchronous process.The data for transfer of the diphenylphosphinoyl and diethylphosphoryl groups between phenolate ion nucleophiles indicates that the identity reaction for the parent phenol has an almost synchronous mechanism for the former phosphinoyl species (τ = 0.92) whereas the latter (τ = 1.45) is almost associative.

Effective Charge Development in Ester Hydrolysis Catalyzed by Cationic Micelles

Reaction of hydroxide ion with substituted phenyl laurates is catalyzed by micelles containing CTAB (cetyltrimethylammonium bromide).The observed rate constants for ester consumption obey a Michaelis-Menten-like rate law, kobsd = (kOHKeq + kOHcat)/(Keq + ), where kOHcat is the second order rate constant for reaction of hydroxide ion with micelle-bound ester, Keq is a partition coefficient for dissociation of ester from the micelle-bound ester, and kOH is the second order rate constant for reaction of free ester with hydroxide ion.The value of the parameter Keq is independent of the nature of the substituent on the ester.The ratio kOHcat/Keq represents the free energy change from ester in aqueous solution to the transition state of the ester reaction in the micellar pseudophase.The dependence of log kOHcat/Keq on the pKa of the leaving phenol obeys a linear Bronsted equation with β1g = -0.51, and log kOH obeys a linear Bronsted equation with β1g = -0.56.Since both Bronsted parameters refer to catalyzed and uncatalyzed reactions starting from the same standard state (aqueous solution), the effective charge in the transtition state of both reactions is almost the same.The microscopic medium is thus similar for both cases, consistent with the COOAr moiety's residing in an aqueous-like region of the pseudophase in the catalytic process.