165558-80-5

Usage

Uses

Used in Pharmaceutical Industry:
N-methyl-1-(2-(trifluoromethyl)pyridin-4-yl)methanamine is utilized as a pharmaceutical intermediate for the development of various medicinal agents. Its unique structure allows it to serve as a building block in the synthesis of drugs targeting specific biological pathways or receptors, potentially leading to the creation of novel therapeutics.
Used in Research Applications:
In the realm of scientific research, N-methyl-1-(2-(trifluoromethyl)pyridin-4-yl)methanamine is employed as a research chemical. It is used to explore its chemical properties, reactivity, and potential interactions with biological systems, which can contribute to a deeper understanding of its pharmacological profile and possible applications in drug discovery.
Used in Chemical Synthesis:
N-methyl-1-(2-(trifluoromethyl)pyridin-4-yl)methanamine is also used as a key component in the synthesis of more complex organic molecules. Its versatile structure makes it a valuable precursor in the creation of a variety of compounds with potential applications in different industries, including materials science, agrochemicals, and specialty chemicals.

InChI:InChI=1/C8H9F3N2/c1-12-5-6-2-3-13-7(4-6)8(9,10)11/h2-4,12H,5H2,1H3

Upstream product

• 131747-61-0 <2-(trifluoromethyl)pyridin-4-yl>methanol 
• 1027545-48-7 4-(chloromethyl)-2-(trifluoromethyl)pyridine 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Preparation of benzindole compounds from naphthalene compounds

The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: STR1 The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyanonaphthalene compound and its precursors are also described.

Synthesis and Biological Evaluation of Novel 2,6-Diaminobenzindole Inhibitors of Thymidylate Synthase Using the Protein Structure as a Guide

The design, synthesis, and biochemical and biological evaluations of a novel series of 2,6-diaminobenzindole-containing inhibitors of human thymidylate synthase (TS) are described.The compounds are characterized by having either a pyridine or pyridazine ring in place of the (phenylsulfonyl)morpholinyl group of the known inhibitor N6--N6-methyl-2,6-diaminobenzindole glucuronate (i).Active compounds from this series showed human TS inhibition constants below the 10 nM level and were potent, selective submicromolar antitumor agents in cell culture.The compounds were synthesized by reductive alkylation of a substituted 6-aminobenzindole or reductive cyclization of a substituted 1-cyano-8-nitronaphthalene.