165560-22-5

Upstream product

• 165560-13-4 1,1-dimethylethyl N-<(1R,2S,3R)-2,3-bis(tert-butyldimethylsilyloxy)-3-methoxycarbonyl-1-trityloxymethylpropanyl>carbamate 
• 165560-20-3 (2R,3S,4S)-N-tert-butoxycarbonyl-3,4-bis(tert-butyldimethylsilyloxy)-2-trityloxymethylpyrrolidine 

Downstream Products

• 127298-72-0 (2R,3S,4S)-N-benzyl-3,4-bis(benzyloxy)-2-hydroxymethylpyrrolidine 
• 27958-05-0 (2R,3S,4S)-N-(benzyloxycarbonyl)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine 

Relevant academic research and scientific papers

SYNTHESIS OF (2R,3R,4R,5R)-3,4-DIHYDROXY-2,5-DIHYDROXYMETHYLPYRROLIDINE AND (-)-ANISOMYCIN DERIVATIVE FROM (S)-PYROGLUTAMIC ACID DERIVATIVE

Double asymmetric dihydroxylation of (E)-α,β-unsaturated ester (2) with a catalitic amount of potassium osmate and chiral ligand gave dihydroxy compounds (3a and 4a) selectively.Polyhydroxylated pyrrolidines (10 and 14) were synthesized from corresponding methoxymethyl ether (3c) and tert-butyl-dimethylsilyl ether (4d), respectively.