1656-48-0

Basic information

• Product Name: 2-Cyanoethyl ether
• Synonyms: TIMTEC-BB SBB007789;.beta.,.beta.’-Oxydipropionitrile;2,2’-oxydiethankarbonitril;2,2'-Oxydiethankarbonitril;3,3’-oxybis-propanenitril;3,3’-Oxybispropanenitrile;3,3’-oxybis-Propanenitrile;3,3’-oxydi-propionitril
• CAS NO: 1656-48-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 216-750-9
• Product Categories: Dinitriles;Dinitriles & Trinitriles;Gas Chromatography;Packed GC;Stationary Phases;Building Blocks;C6 to C7;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
• Mol File: 1656-48-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: -26 °C
• Boiling Point: 143 °C
• Flash Point: >230 °F
• Appearance: clear colourless to very slightly brownish liquid
• Density: 1.043 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000488mmHg at 25°C
• Refractive Index: n20/D 1.441(lit.)
• Water Solubility: Soluble in water
• BRN: 1746454
• CAS DataBase Reference: 2-Cyanoethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyanoethyl ether(1656-48-0)
• EPA Substance Registry System: 2-Cyanoethyl ether(1656-48-0)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 23-24/25-36/37/39-26
• WGK Germany: 2
• RTECS: UG4200000
• TSCA: Yes
• Hazardous Substances Data: 1656-48-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to very slightly brownish liquid

Safety Profile

Moderately toxic by ingestion. An eye irritant. When heated to decomposition it emits toxic fumes of NOx and CNí.

InChI:InChI=1/C6H8N2O/c7-3-1-5-9-6-2-4-8/h1-2,5-6H2

Upstream product

• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 107-13-1 acrylonitrile 
• 123-31-9 hydroquinone 
• 123-91-1 1,4-dioxane 
• 109-78-4 3-Hydroxypropionitrile 
• 75-65-0 tert-butyl alcohol 
• 589-55-9 heptan-4-ol 
• 111-70-6 n-heptan1ol 
• 56-81-5 glycerol 
• 107-21-1 ethylene glycol 
• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 115-77-5 Pentaerythritol 
• 151-50-8 potassium cyanide 

Downstream Products

• 74267-34-8 N,N,N',N'-Tetraphenyl-4-oxaheptandiamid 
• 55005-96-4 oxybis(propane-3,1-diyl) bis(4-methylbenzenesulfonate) 
• 1612884-40-8 C₆₂H₈₂N₄O₁₁ 
• 1612884-38-4 C₆₂H₇₈N₂O₁₆ 
• 1612884-37-3 3-[2-(3-tert-butyl-5-formyl-4-hydroxyphenoxycarbonyl)ethoxy]propionic acid 
• 107-13-1 acrylonitrile 
• 109-78-4 3-Hydroxypropionitrile 
• 58929-41-2 [3-(4-Chloro-phenoxy)-propyl]-(3-{3-[[3-(4-chloro-phenoxy)-propyl]-(2-methoxy-ethyl)-amino]-propoxy}-propyl)-(2-methoxy-ethyl)-amine 
• 58929-37-6 [2-(2-Chloro-phenoxy)-ethyl]-(3-{3-[[2-(2-chloro-phenoxy)-ethyl]-(2-methoxy-ethyl)-amino]-propoxy}-propyl)-(2-methoxy-ethyl)-amine 
• 58929-39-8 [2-(4-Chloro-phenoxy)-ethyl]-(3-{3-[[2-(4-chloro-phenoxy)-ethyl]-(2-methoxy-ethyl)-amino]-propoxy}-propyl)-(2-methoxy-ethyl)-amine 
• 116073-79-1 C₆₆H₉₄N₆O₁₄S₂ 
• 116073-81-5 C₄₅H₅₇N₃O₁₂ 
• 116102-08-0 5,13-bis(4'-methoxycarbonylbenzoyl)-21-tosyl-1,9,17-trioxa-5,13,21-triazacyclotetracosane 
• 116073-82-6 5,13,21-tris(4-carboxybenzoyl)-1,9,17-trioxa-5,13,21-triazacyclotetracosane 

Relevant articles and documents

Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery

In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds of formula (I) useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Synthesis of and catalytic nitrile hydration by a cationic tris(μ-hydroxo)diruthenium(II) complex having PMe3ligands

While phenyl vinyl ether does not react with [Ru(η4-1,5-COD)(η6-1,3,5-COT)] (1)/PMe3, the C–O bond cleavage of phenyl vinyl ether occurs by 1/PMe3in the presence of water to give a tris(μ-hydroxo)diruthenium(II) complex [(Me3P)3Ru(μ-OH)3Ru(PMe3)3]+[OPh]?·HOPh (3·HOPh) with evolution of ethylene. The molecular structure of 3·HOPh is unequivocally determined by X-ray analysis. The most likely mechanism for the formation of 3·HOPh is protonation of [Ru(η4-1,5-COD)(PMe3)3] (2c) by water and subsequent insertion of phenyl vinyl ether into the resulting Ru–H bond followed by the β-phenoxide elimination and hydrolysis and dimerization of the phenoxoruthenium(II) species. Complex 3 acts as a catalyst for nitrile hydration. As a typical example, the hydration of benzonitrile was achieved by 3 (1.0 mol%) in 1,4-dioxane at 120 °C for 6 h to give benzamide quantitatively.