16563-45-4

Upstream product

• 541-35-5 butanamide 
• 157129-57-2 4-(naphth-1-yloxy)-N,N-pentamethylenebutyramide 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 90-15-3 α-naphthol 
• 96-48-0 4-butanolide 

Relevant academic research and scientific papers

Rational hapten design to produce high-quality antibodies against carbamate pesticides and development of immunochromatographic assays for simultaneous pesticide screening

Carbamate pesticides (CPs) are the most used pesticides in agricultural production and pest control. In this study, carbofuran, isoprocarb and carbaryl were employed as models, and a general hapten strategy based on carbamate moiety recognition was propos

9,10-dihydro-8H-11-oxa-cyclohepta[a]naphthalen-7-one: Crystallographic, computational and Hirshfeld surface analysis

9,10-Dihydro-8H-11-oxa-cyclohepta[a]naphthalen-7-one has been synthesized and characterized by elemental analysis, IR, 1H NMR spectroscopy, mass spectrometry and finally by X-ray crystallography. X-ray diffraction studies indicates that the molecule is stabilized by C- H···O and C-H···π non-covalent interactions in the solid state. Quantum chemical calculations and Hirshfeld surface analysis have been performed to gain insight into the behavior of these weak interactions. Graphical Abstract: 9,10-Dihydro-8H-11-oxa-cyclohepta [a]naphthalen-7-one has been synthesized and characterized. The nature of its weak Ar-H···π and C-H···O interactions have been addressed by DFT, AIM and Hirshfeld surface analysis.[Figure not available: see fulltext.]

Potential hypotensive agents: Synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds

The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2-b]- and naphth[2,1-b]-oxepin-5-ones (4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80mm/Hg for >100′ at a dose of 5mg/kg iv in anaesthetized cats.

1- and 2-substituted naphthalenes: A new class of potential hypotensive agents

A series of 2-substituted aminomethyloxy naphthalenes 1 and 4-(1-naphthoxy-2-substituted aminomethyl)-butanoic acids 2 were synthesized by Mannich reaction of 4-(2-naphthoxy)-butanoic acid 3 and 4-(1-naphthoxy)-butanoic acid 4 with appropriate secondary amines and para-formaldehyde. The newly synthesized compounds were tested for their hypotensive activity at 5mg/kgiv dose in cats. The results indicated that the analogue 2-(N4-phenyl- N1-piperazino)-methyloxy naphthalene 1d (>N=N4-phenyl- N1-piperazino) was the most active analogue when its hypotensive activity was compared to the reference compound propranolol.

An improved two-step regioselective synthesis of naphth- and naphthoxepin-5-ones

An improved regioselective synthesis of naphthoxepin-5-one 1 and naphthoxepin-5-one 2 has been described. The key step is one-step regioselective synthesis of 4-naphthoxybutanoic acids 3 and 4, formed from the corresponding naphthols, and their cyclisation to naphthoxepinones 1 and 2.

Heterocyclic amines

Heterocyclic amines of the formula wherein Ar is a bicyclic or tricyclic aromatic group which is unsubstituted or which bears one or more substituents selected from halo, nitro and cyano groups and alkyl and alkoxy groups each of up to 4 carbon atoms; wherein X is a direct link or is --O--, --S--, --SO-- or --SO2 -- or has the formula --C(R3)=CH-- wherein R3 is hydrogen or alkyl of up to 4 carbon atoms; wherein A is straight or branched alkylene or alkenylene of 3 to 8 carbon atoms which may be interrupted by --O--, --S-- or --NH--; and wherein NR1 R2 is a cyclic amino group; or a pharmaceutically acceptable acid addition salt thereof, are of value for therapeutic use, particularly in the treatment of myocardial ischaemia and hypertension and in the treatment of fungal infections.