16565-48-3Relevant academic research and scientific papers
Ru-Catalyzed [3 + 2] Cycloaddition of Nitrile Oxides and Electron-Rich Alkynes with Reversed Regioselectivity
Feng, Qiang,Huang, Hai,Sun, Jianwei
, p. 2431 - 2436 (2021/05/05)
Polarity reversal ("umpolung") of a functional group can override its inherent reactivity and lead to distinct bond-forming modes. Herein we describe a rarely studied cycloaddition between nitrile oxides and electron-rich alkynes with reversed regioselect
Synthesis of 3,4,5-trisubstituted isoxazoles by the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes
Hu, Manman,He, Xinwei,Niu, Zhiqiang,Yan, Zhenglei,Zhou, Fuyin,Shang, Yongjia
, p. 510 - 514 (2014/03/21)
A novel, one-pot, cascade reaction sequence featuring the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes was developed. This procedure provides an efficient, straightforward and metal-free method for the synthesis of 3,4,5-trisubstituted isoxazoles under mild reaction conditions.
