165669-14-7

Basic information

• Product Name: 3-CHLORO-7-NITRO-1H-INDOLE
• Synonyms: 3-CHLORO-7-NITRO-1H-INDOLE;3-CHLORO-7-NITRO-INDOLE;1H-Indole, 3-chloro-7-nitro-
• CAS NO: 165669-14-7
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.59
• Product Categories: Indole
• Mol File: 165669-14-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 395.7 °C at 760 mmHg
• Flash Point: 193.1 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 4.1E-06mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 2-8°C
• PKA: 12.38±0.30(Predicted)
• CAS DataBase Reference: 3-CHLORO-7-NITRO-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-7-NITRO-1H-INDOLE(165669-14-7)
• EPA Substance Registry System: 3-CHLORO-7-NITRO-1H-INDOLE(165669-14-7)

Safety Data

• Hazardous Substances Data: 165669-14-7(Hazardous Substances Data)

Usage

General Description

3-Chloro-7-nitro-1H-indole is a highly specific organic compound that falls under the classification of indoles. This chemical features in many pharmaceuticals and therapeutic compounds, owing to its particular structures and properties. Its molecular formula is C8H5ClN2O2. It is characterized by a chloro group (Cl) at the third position and a nitro group (NO2) at the seventh position in the indole ring. Due to its nitro functionality, this compound can participate in a variety of reactions, making it useful as an intermediate in organic synthesis and pharmaceutical manufacturing. Its physical and chemical properties can markedly affect these processes. As such, understanding these properties aids in improving the effectiveness and efficiency of these reactions. The handling of this chemical requires precautions due to its potential health hazards.

InChI:InChI=1/C8H5ClN2O2/c9-6-4-10-8-5(6)2-1-3-7(8)11(12)13/h1-4,10H

Upstream product

• 6960-42-5 7-nitro-1H-indole 
• 3481-09-2 N-chlorophthalimide 

Downstream Products

• 165668-51-9 4-Carbamoyl-N-(3-chloro-1H-indole-7-yl)benzenesulfonamide 
• 165668-24-6 N-(3-chloro-7-indolyl)-4-nitrobenzenesulfonamide 
• 165668-32-6 N-(3-Chloro-1H-indole-7-yl)-4-cyanobenzenesulfonamide 
• 165668-25-7 4-Amino-N-(3-chloro-1H-indole-7-yl)benzenesulfonamide 
• 165669-13-6 7-amino-3-chloro-1H-indole 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Lactam inhibitors of factor Xa and method

Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, 1011 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.

Heterobicyclic sulfonamide and sulfonic ester derivatives

Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula(I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof. A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: STR1 wherein A represents a monocyclic or bicyclic aromatic ring which may be substituted; B represents a six-membered unsaturated hydrocarbon ring or a six-membered unsaturated heterocycle containing one nitrogen atom, each of which may be substituted; C represents a five-membered heterocycle containing one or two nitrogen atoms which may be substituted; W represents a single bond or a group represented by formula --CH=CH--; X represents a group represented by formula --N(R1)-- or oxygen; Y represents carbon or nitrogen; Z represents a group represented by formula --N(R2)-- or nitrogen; and R1 and R2 may be the same or different from each other and each represent hydrogen or lower alkyl.