165668-25-7Relevant academic research and scientific papers
A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors
Owa, Takashi,Okauchi, Tatsuo,Yoshimatsu, Kentaro,Sugi, Naoko Hata,Ozawa, Yoichi,Nagasu, Takeshi,Koyanagi, Nozomu,Okabe, Tadashi,Kitoh, Kyosuke,Yoshino, Hiroshi
, p. 1223 - 1226 (2007/10/03)
A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. (C) 2000 Elsevier Science Ltd. All rights reserved.
Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle
Owa, Takashi,Yoshino, Hiroshi,Okauchi, Tatsuo,Yoshimatsu, Kentaro,Ozawa, Yoichi,Sugi, Naoko Hata,Nagasu, Takeshi,Koyanagi, Nozomu,Kitoh, Kyosuke
, p. 3789 - 3799 (2007/10/03)
Described herein is the discovery of a novel series of antitumor sulfonamides targeting G1 phase of the cell cycle. Cell cycle control in G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins invol
