165669-21-6

Usage

Uses

Used in Research Applications:
Ethanone, 1-(7-nitro-1H-indol-3-yl)is used as a research compound for exploring its chemical properties and potential interactions with biological systems. Its unique structure allows for investigation into various chemical reactions and the development of novel organic molecules with specific properties or functions.
Used in Pharmaceutical Applications:
Ethanone, 1-(7-nitro-1H-indol-3-yl)is used as a pharmaceutical intermediate for the synthesis of potential drug candidates. Its reactivity and functional groups can be utilized in the development of new therapeutic agents, particularly in the field of drug discovery and development.
Used in Drug Discovery and Development:
Ethanone, 1-(7-nitro-1H-indol-3-yl)is used as a key component in the synthesis of novel organic molecules with potential therapeutic applications. Its presence in the compound may contribute to the development of new drugs with improved efficacy and selectivity.
Used in Synthesis of Novel Organic Molecules:
Ethanone, 1-(7-nitro-1H-indol-3-yl)is used as a building block in the synthesis of complex organic molecules with specific properties or functions. Its versatility in chemical reactions enables the creation of a wide range of compounds with potential applications in various fields of science and technology.
Further studies and investigations are needed to fully explore the potential applications and benefits of Ethanone, 1-(7-nitro-1H-indol-3-yl)in different fields of science and technology.

Upstream product

• 6960-42-5 7-nitro-1H-indole 
• 75-36-5 acetyl chloride 
• 1184-58-3 dimethylaluminum chloride 

Downstream Products

• 1311395-39-7 3-acetyl-N-[4-(methylphenyl)sulfonyl]-7-nitro-1H-indole 

Relevant academic research and scientific papers

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives

The synthesis of new meridianin derivatives is described. The indolic ring system was substituted at the C-4 to C-7 positions either by a bromine atom or by nitro or amino groups. Additionally, an iodine atom or various aryl groups were introduced at the C-5 position of the 2-aminopyrimidine ring. These compounds as well as some of their synthetic intermediates were tested for their kinase inhibitory potencies and for their in vitro antiproliferative activities. We found that this series of compounds is particularly interesting in the development of new inhibitors of DYRK1A and CLK1 kinases. The most effective compounds toward these two kinase families are the 6- and 7-bromo derivatives 30, 33, and 34 that showed more than 45-fold selectivity toward DYRK1A/CLK1 kinases over the other kinases tested. Meridianin derivatives could thus be developed toward potent and selective inhibitors of key RNA splicing regulators and potential therapeutic agents.

Integrin expression inhibitors

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

A general method for acylation of indoles at the 3-position with acyl chlorides in the presence of dialkylaluminum chloride.

[reaction--see text] Indoles are selectively acylated at the 3-position in high yields on treatment with a wide variety of acyl chlorides in CH(2)Cl(2) in the presence of diethylaluminum chloride or dimethylaluminum chloride. The reaction proceeds under mild conditions and is applicable to indoles bearing various functional groups without NH protection.

Heterobicyclic sulfonamide and sulfonic ester derivatives

Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula(I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof. A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: STR1 wherein A represents a monocyclic or bicyclic aromatic ring which may be substituted; B represents a six-membered unsaturated hydrocarbon ring or a six-membered unsaturated heterocycle containing one nitrogen atom, each of which may be substituted; C represents a five-membered heterocycle containing one or two nitrogen atoms which may be substituted; W represents a single bond or a group represented by formula --CH=CH--; X represents a group represented by formula --N(R1)-- or oxygen; Y represents carbon or nitrogen; Z represents a group represented by formula --N(R2)-- or nitrogen; and R1 and R2 may be the same or different from each other and each represent hydrogen or lower alkyl.