165682-80-4 Usage
Uses
Used in Pharmaceutical Industry:
2-(4-Bromo-phenylamino)-thiazole-4-carboxylic acid serves as a key building block in the synthesis of various drug candidates and bioactive molecules. Its multifaceted biological activities, including antimicrobial, antitumor, and anti-inflammatory properties, make it instrumental in the creation of novel therapeutic agents.
Used in Medicinal Chemistry Research:
As a compound with demonstrated potential across several therapeutic areas, 2-(4-Bromo-phenylamino)-thiazole-4-carboxylic acid is utilized as a subject of study for further exploration and development. Its unique structure and the breadth of its biological impact are of particular interest to researchers seeking to understand and harness its properties for medicinal applications.
Used in Drug Discovery:
2-(4-Bromo-phenylamino)-thiazole-4-carboxylic acid is employed as a starting point for drug discovery efforts, given its established potential to contribute to the development of new pharmaceuticals with diverse therapeutic effects. Its versatility in chemical modifications allows for the exploration of various derivatives that could lead to effective treatments for a range of diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 165682-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,6,8 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 165682-80:
(8*1)+(7*6)+(6*5)+(5*6)+(4*8)+(3*2)+(2*8)+(1*0)=164
164 % 10 = 4
So 165682-80-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H7BrN2O2S/c11-6-1-3-7(4-2-6)12-10-13-8(5-16-10)9(14)15/h1-5H,(H,12,13)(H,14,15)
165682-80-4Relevant academic research and scientific papers
Synthesis and cellular uptake of p-[123I]-phenyl-amino-thiazole (123I-PAT) as a potential agent for targeting tubulin polymerization in tumors
Wang, Da-Ming,Kuo, Jia-Wei,Kuo, Wei-Ti,Hsu, Cheng-Fang,Wang, Mei-Hui,Chang, Yu,Lin, Wuu-Jyh,Wang, Jen-Tsung
, p. 132 - 135 (2014/04/03)
The phenyl-amino-thiazole (PAT) templates of methoxylbenzoyl-aryl-thiazole are potent agents against cancer by inhibiting tubulin polymerization in the nanomolar range. Herein, a radioiodinated PAT, [123I]-PAT 1, was prepared via a tributylstannyl precursor and [123I]iodide through electrophilic aromatic radioiodination. Radiolabelling of [123I]-PAT 1 was achieved in less than 15 min, with a radiochemical purity of over 99%. The accumulated radioactivity in tumor cellular uptake experiments suggested that [123I]-PAT could serve as a potential radioprobe for targeting tumor cells. Copyright
5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY
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Page/Page column 57-58, (2010/11/08)
The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y1, Y2, R1, n, R3, R8, R9, R10, L1, L2, Ar1 and Ar2 are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
