1592875-28-9

Upstream product

• 165682-80-4 2-(4-bromophenylamino)thiazole-4-carboxylic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 165682-91-7 ethyl 2-((4-bromophenyl)amino)thiazole-4-carboxylate 
• 2646-30-2 1-(4-bromophenyl)thiourea 

Downstream Products

• 1592875-35-8 (2-(4-tributylstannylphenylamino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1592875-31-4 N-methoxy-N-methyl-2-(4-tributylstannylphenylamino)thiazole-4-carboxamide 

Relevant academic research and scientific papers

Synthesis and cellular uptake of p-[123I]-phenyl-amino-thiazole (123I-PAT) as a potential agent for targeting tubulin polymerization in tumors

The phenyl-amino-thiazole (PAT) templates of methoxylbenzoyl-aryl-thiazole are potent agents against cancer by inhibiting tubulin polymerization in the nanomolar range. Herein, a radioiodinated PAT, [123I]-PAT 1, was prepared via a tributylstannyl precursor and [123I]iodide through electrophilic aromatic radioiodination. Radiolabelling of [123I]-PAT 1 was achieved in less than 15 min, with a radiochemical purity of over 99%. The accumulated radioactivity in tumor cellular uptake experiments suggested that [123I]-PAT could serve as a potential radioprobe for targeting tumor cells. Copyright